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Hypoxia-inducible factor 1 (HIF-1) pathway

scientific article published on 09 October 2007

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Europe PubMed Central

17 August 2017

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Europe PubMed Central

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Hypoxia-inducible factor 1 (HIF-1) pathway (English)

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Europe PubMed Central

17 August 2017

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Gregg L Semenza

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Europe PubMed Central

17 August 2017

9 October 2007

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Europe PubMed Central

17 August 2017

Science's STKE : signal transduction knowledge environment

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Europe PubMed Central

17 August 2017

2007

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Europe PubMed Central

17 August 2017

cm8

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Europe PubMed Central

17 August 2017

407

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Europe PubMed Central

17 August 2017

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Harnessing the hypoxia-inducible factor in cancer and ischemic disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Evaluation of HIF-1 inhibitors as anticancer agents

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Hydroxylation of HIF-1: oxygen sensing at the molecular level

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/STKE.4072007CM8

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DOI

10.1126/STKE.4072007CM8

1 reference

stated in

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

PubMed ID

17925579

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17 August 2017

(Q36966537)

Hypoxia-inducible factor 1 (HIF-1) pathway

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