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Evaluation of HIF-1 inhibitors as anticancer agents

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Europe PubMed Central

title

Evaluation of HIF-1 inhibitors as anticancer agents (English)

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Gregg L Semenza

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language of work or name

English

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publication date

October 2007

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published in

Drug Discovery Today

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volume

12

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page(s)

853-9

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issue

19-20

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cites work

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1alpha-mediated tumor apoptotic switch

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Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells

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Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

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Induction ofID2Expression by Hypoxia-inducible Factor-1

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Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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12 October 2022

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding

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12 October 2022

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Regulation of DNA repair in hypoxic cancer cells

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

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https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia: a key regulator of angiogenesis in cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia inducible factor-1alpha is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Effects of hypoxia on tumor metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Regulation of tumor pH and the role of carbonic anhydrase 9.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Baffled by bafilomycin: an anticancer agent that induces hypoxia-inducible factor-1alpha expression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Metastasis and stem cell pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Development of novel therapeutic strategies that target HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia and adaptive landscapes in the evolution of carcinogenesis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Endostatin's antiangiogenic signaling network

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

GL331 inhibits HIF-1alpha expression in a lung cancer model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factors and hypoxic cell death in tumour physiology

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia, gene expression, and metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Expression of hypoxia-inducible factor-1alpha protein predicts survival in patients with transitional cell carcinoma of the upper urinary tract.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Evaluation of hypoxia-inducible factor 1alpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia-driven selection of the metastatic phenotype

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia in cancer: significance and impact on clinical outcome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Design of clinical trials of radiation combined with antiangiogenic therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Genetic evidence for a tumor suppressor role of HIF-2alpha.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.DRUDIS.2007.08.006

Identifiers

DOI

10.1016/J.DRUDIS.2007.08.006

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

711738

Fatcat ID

release_tdccmu5pn5a57do2ggfzcxrt4i

1 reference

stated in

Fatcat

reference URL

https://api.fatcat.wiki/v0/release/tdccmu5pn5a57do2ggfzcxrt4i

retrieved

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

711738

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

711738

(Q28253053)

Evaluation of HIF-1 inhibitors as anticancer agents

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