(Q40439596)

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The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

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scholarly article

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Europe PubMed Central

20 September 2017

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression (English)

1 reference

Europe PubMed Central

20 September 2017

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author name string

Rodney B Luwor

1

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Europe PubMed Central

20 September 2017

Yang Lu

2

1 reference

Europe PubMed Central

20 September 2017

Xinqun Li

3

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Europe PubMed Central

20 September 2017

John Mendelsohn

4

1 reference

Europe PubMed Central

20 September 2017

Zhen Fan

5

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Europe PubMed Central

20 September 2017

language of work or name

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publication date

1 June 2005

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Europe PubMed Central

20 September 2017

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Europe PubMed Central

20 September 2017

24

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Europe PubMed Central

20 September 2017

27

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Europe PubMed Central

20 September 2017

4433-4441

1 reference

Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208625

0 references

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

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An essential role for p300/CBP in the cellular response to hypoxia

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Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

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Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway

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Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected].

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells.

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The epidermal growth factor receptor mediates radioresistance.

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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Role of CBP in regulating HIF-1-mediated activation of transcription.

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Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway

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MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

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The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

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Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells

1 reference

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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

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United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets

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Therapeutic application of anti-growth factor receptor antibodies

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

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Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor.

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model

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Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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The EGF receptor family as targets for cancer therapy

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ERK activation upon hypoxia: involvement in HIF-1 activation

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Signal transduction by receptors with tyrosine kinase activity

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10.1038/SJ.ONC.1208625

1 reference

Europe PubMed Central

20 September 2017

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1 reference

Europe PubMed Central

20 September 2017

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