(Q74541466)

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Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

scientific article published on 30 July 2002

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149254%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149254%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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11 November 2019

Gregg L. Semenza

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Gregg L Semenza

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11 November 2019

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Ryo Fukuda

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11 November 2019

Fan Fan

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11 November 2019

Young Do Jung

4

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11 November 2019

Lee M Ellis

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11 November 2019

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30 July 2002

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11 November 2019

Journal of Biological Chemistry

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11 November 2019

277

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11 November 2019

41

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11 November 2019

38205-38211

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11 November 2019

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

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Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

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'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

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MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

1 reference

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Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

12 October 2022

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Regulation of translation initiation by FRAP/mTOR

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Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

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Gene expression profiles in normal and cancer cells

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Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 October 2022

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

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Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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IGF-I receptor signalling in transformation and differentiation

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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HIF-1 and tumor progression: pathophysiology and therapeutics

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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Expression of hypoxia-inducible factor 1? in brain tumors

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Identifiers

10.1074/JBC.M203781200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149254%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12149254%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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