(Q37987842)

26 August 2017

Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity (English)

1 reference

26 August 2017

1 reference

Amanda W Lund

2

0 references

author name string

Melody A Swartz

series ordinal

1

1 reference

PubMed ID

22362216

26 August 2017

language of work or name

English

0 references

publication date

24 February 2012

1 reference

26 August 2017

Nature Reviews Cancer

1 reference

26 August 2017

12

1 reference

26 August 2017

210-219

1 reference

26 August 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc3186

26 August 2017

0 references

cites work

Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis

1 reference

Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype

31 March 2020

1 reference

Resistance of tumor interstitial pressure to the penetration of intraperitoneally delivered antibodies into metastatic ovarian tumors

31 March 2020

1 reference

Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix.

31 March 2020

1 reference

The microanatomy of T-cell responses

31 March 2020

1 reference

Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex

31 March 2020

1 reference

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize

31 March 2020

1 reference

Hallmarks of Cancer: The Next Generation

31 March 2020

1 reference

Balancing forces: architectural control of mechanotransduction

31 March 2020

1 reference

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

31 March 2020

1 reference

High interstitial fluid pressure - an obstacle in cancer therapy

31 March 2020

1 reference

Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer

31 March 2020

1 reference

Quantitative imaging of lymphatic function with liposomal indocyanine green

31 March 2020

1 reference

Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm

31 March 2020

1 reference

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.

31 March 2020

1 reference

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.

31 March 2020

1 reference

Lymphangiogenesis, myeloid cells and inflammation

31 March 2020

1 reference

VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes

31 March 2020

1 reference

Lymphangiogenesis: Molecular mechanisms and future promise

31 March 2020

1 reference

Lymphangiogenesis in post-natal tissue remodeling: lymphatic endothelial cell connection with its environment

31 March 2020

1 reference

Integrins in angiogenesis and lymphangiogenesis

31 March 2020

1 reference

Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma

31 March 2020

1 reference

Lymphangiogenesis and cancer metastasis

31 March 2020

1 reference

Dynamic contrast-enhanced magnetic resonance imaging of tumor-induced lymph flow

31 March 2020

1 reference

Interstitial flow as a guide for lymphangiogenesis

31 March 2020

1 reference

Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro.

31 March 2020

1 reference

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism.

31 March 2020

1 reference

Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function

31 March 2020

1 reference

Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis

31 March 2020

1 reference

High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight

31 March 2020

1 reference

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts

31 March 2020

1 reference

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

31 March 2020

1 reference

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro.

31 March 2020

1 reference

Interstitial flow influences direction of tumor cell migration through competing mechanisms.

31 March 2020

1 reference

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching

31 March 2020

1 reference

Non-linear elasticity of extracellular matrices enables contractile cells to communicate local position and orientation

31 March 2020

1 reference

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

31 March 2020

1 reference

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

31 March 2020

1 reference

Forcing form and function: biomechanical regulation of tumor evolution

31 March 2020

1 reference

Tensional homeostasis and the malignant phenotype

31 March 2020

1 reference

Collagen density promotes mammary tumor initiation and progression

31 March 2020

1 reference

Breast cancer by proxy: can the microenvironment be both the cause and consequence?

31 March 2020

1 reference

Aligned collagen is a prognostic signature for survival in human breast carcinoma

31 March 2020

1 reference

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

31 March 2020

1 reference

Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines.

31 March 2020

1 reference

Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

1 reference

31 March 2020

Fibroblasts in cancer

1 reference

Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

31 March 2020

1 reference

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

31 March 2020

1 reference

Determinants of leader cells in collective cell migration

31 March 2020

1 reference

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

1 reference

Collagen reorganization at the tumor-stromal interface facilitates local invasion

31 March 2020

1 reference

Collective cell migration in morphogenesis, regeneration and cancer

31 March 2020

1 reference

Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization

31 March 2020

1 reference

Fluid shear stress regulates the invasive potential of glioma cells via modulation of migratory activity and matrix metalloproteinase expression

31 March 2020

1 reference

Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1

31 March 2020

1 reference

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

31 March 2020

1 reference

The tumor-draining lymph node as an immune-privileged site

31 March 2020

1 reference

Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients

31 March 2020

1 reference

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

31 March 2020

1 reference

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.

31 March 2020

1 reference

Lymph node tumor metastases: more susceptible than primary tumors to CD8(+) T-cell immune destruction

31 March 2020

1 reference

Extralymphatic tumors prepare draining lymph nodes to invasion via a T-cell cross-tolerance process

31 March 2020

1 reference

Plasmacytoid dendritic cells represent a major dendritic cell subset in sentinel lymph nodes of melanoma patients and accumulate in metastatic nodes

31 March 2020

1 reference

Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer.

31 March 2020

1 reference

Tumour immunity: effector response to tumour and role of the microenvironment

31 March 2020

1 reference

Transforming growth factor beta (TGF-beta) and inflammation in cancer

31 March 2020

1 reference

The polarization of immune cells in the tumour environment by TGFbeta

31 March 2020

1 reference

Roles of TGFbeta in metastasis

31 March 2020

1 reference

Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta

31 March 2020

1 reference

Myeloid-derived suppressor cells as regulators of the immune system

31 March 2020

1 reference

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

31 March 2020

1 reference

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation

31 March 2020

1 reference

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

31 March 2020

1 reference

CCR7 and its ligands: balancing immunity and tolerance

31 March 2020

1 reference

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

31 March 2020

1 reference

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

31 March 2020

1 reference

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype

31 March 2020

1 reference

Microglia/macrophages promote glioma progression

31 March 2020

1 reference

Expression and function of T cell homing molecules in Hodgkin's lymphoma

31 March 2020

1 reference

Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

31 March 2020

1 reference

Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

31 March 2020

1 reference

Inflammation recapitulates the ontogeny of lymphoid stromal cells.

31 March 2020

1 reference

Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses

31 March 2020

1 reference

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

31 March 2020

1 reference

Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells

31 March 2020

1 reference

Generalized multi-organ autoimmunity in CCR7-deficient mice

31 March 2020

1 reference

VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

31 March 2020

1 reference

An important role of lymphatic vessel activation in limiting acute inflammation

31 March 2020

1 reference

Role of the lymphatic system in the pathogenesis of Crohn's disease

31 March 2020

1 reference

Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival

31 March 2020

1 reference

Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates

31 March 2020

1 reference

Crucial role of corneal lymphangiogenesis for allograft rejection in alkali-burned cornea bed

31 March 2020

1 reference

Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies

31 March 2020

1 reference

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

31 March 2020

1 reference

B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes

31 March 2020

1 reference

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

31 March 2020

1 reference

The contribution of B cells to renal interstitial inflammation

31 March 2020

1 reference

Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure

31 March 2020

1 reference

Is defective lymphatic drainage a trigger for lymphoid neogenesis?

31 March 2020

1 reference

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism

31 March 2020

1 reference

Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

31 March 2020

1 reference

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

31 March 2020

1 reference

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

31 March 2020

1 reference

An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma.

31 March 2020

1 reference

The who, how and where of antigen presentation to B cells

31 March 2020

1 reference

Antigen presentation to naive CD4 T cells in the lymph node.

31 March 2020

1 reference

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

31 March 2020

1 reference

Immunologic tolerance: role of the regional lymph node.

31 March 2020

1 reference

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

31 March 2020

1 reference

Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis

31 March 2020

1 reference

The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.

31 March 2020

1 reference

Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro

31 March 2020

1 reference

Impaired lymphatic contraction associated with immunosuppression

31 March 2020

1 reference

Lymph node stroma broaden the peripheral tolerance paradigm

31 March 2020

1 reference

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

31 March 2020

1 reference

Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model

31 March 2020

1 reference

The conduit system of the lymph node

31 March 2020

1 reference

The influence of afferent lymphatic vessel interruption on vascular addressin expression

31 March 2020

1 reference

Interstitial fluid pressure in DMBA-induced rat mammary tumours

31 March 2020

1 reference

12 December 2020

The role of podoplanin in tumor progression and metastasis.

1 reference

12 December 2020

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber.

1 reference

12 December 2020

Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells

1 reference

12 December 2020

Evaluation of methodologies for measurement of interstitial fluid pressure (Pi): physiological implications of recent Pi data

1 reference

12 December 2020

Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin

1 reference

12 December 2020

Types of reaction in the regional lymph nodes in non-metastatic and minute-metastatic carcinoma of the uterine cervix

1 reference

12 December 2020

Bulk transfer of fluid in the interstitial compartment of mammary tumors

1 reference

12 December 2020

Tumor angiogenesis and interstitial hypertension

1 reference

12 December 2020

Podoplanin expression in cancerous stroma induces lymphangiogenesis and predicts lymphatic spread and patient survival

1 reference

12 December 2020

VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3186

1 reference

PubMed ID

22362216

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22362216