(Q37993591)

26 August 2017

title

Lessons from genome-wide association studies findings in Alzheimer's disease (English)

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genome-wide association study

26 August 2017

main subject

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Alzheimer's disease

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author name string

Clayton F Moraes

1

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26 August 2017

Tulio C Lins

2

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26 August 2017

Einstein F Carmargos

3

1 reference

26 August 2017

Janeth O S Naves

4

1 reference

26 August 2017

Rinaldo W Pereira

5

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26 August 2017

Otávio T Nóbrega

6

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26 August 2017

language of work or name

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27 October 2011

1 reference

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

26 August 2017

published in

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26 August 2017

volume

12

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26 August 2017

issue

1

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26 August 2017

page(s)

62-73

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The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study

26 August 2017

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Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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More missense in amyloid gene.

21 January 2018

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A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene

21 January 2018

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Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

21 January 2018

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An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).

21 January 2018

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21 January 2018

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21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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21 January 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

21 January 2018

1 reference

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

21 January 2018

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Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease.

21 January 2018

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Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.

21 January 2018

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Direct visualization of the microtubule lattice seam both in vitro and in vivo

21 January 2018

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Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport

21 January 2018

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Tau Proteins and Neurofibrillary Degeneration

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Tau protein and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Tau phosphorylation in neuronal cell function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

A common inversion under selection in Europeans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Genetic variability in CLU and its association with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Polymorphisms in the human apolipoprotein-J/clusterin gene: ethnic variation and distribution in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Synaptic distribution of the endocytic accessory proteins AP180 and CALM

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Distribution and Expression of Picalm in Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Replication of CLU, CR1, and PICALM associations with alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Complement biosynthesis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The significance of neuroinflammation in understanding Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Inflammation in neurodegenerative disease--a double-edged sword

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Inflammation in the nervous system--physiological and pathophysiological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The role of inflammation in CNS injury and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The role of inflammation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Glia and their cytokines in progression of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Finding the missing heritability of complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Gerontology in the developing Brazil: achievements and challenges in public policies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1479-8301.2011.00378.X

10.1111/J.1479-8301.2011.00378.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference