(Q37998135)

26 August 2017

title

Ion channel drug discovery: challenges and future directions (English)

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26 August 2017

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A Wickenden

1

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26 August 2017

B Priest

series ordinal

2

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26 August 2017

G Erdemli

series ordinal

3

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26 August 2017

publication date

1 April 2012

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Future Medicinal Chemistry

26 August 2017

published in

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26 August 2017

volume

4

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26 August 2017

issue

5

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26 August 2017

page(s)

661-679

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The molecular cloning and characterisation of cDNA coding for the α subunit of the acetyl-choline receptor

26 August 2017

cites work

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21 January 2018

Ion channel screening

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Varenicline in smoking cessation

21 January 2018

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Intrathecal ziconotide for refractory pain

21 January 2018

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Tolerability and safety of perampanel: two randomized dose-escalation studies.

21 January 2018

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Update on local anesthetics

21 January 2018

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Diversity of calcium antagonists

21 January 2018

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Sodium and potassium balance depends on αENaC expression in connecting tubule

21 January 2018

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Hereditary Channelopathies in Neurology

21 January 2018

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The genetic and clinical features of cardiac channelopathies.

21 January 2018

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From genes to pain: Na v 1.7 and human pain disorders

21 January 2018

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An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

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Hereditary renal tubular disorders

21 January 2018

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Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population

21 January 2018

1 reference

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

21 January 2018

1 reference

Voltage-gated calcium channels and pain

21 January 2018

1 reference

Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels

21 January 2018

1 reference

Non-conducting functions of voltage-gated ion channels

21 January 2018

1 reference

Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.

21 January 2018

1 reference

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion

21 January 2018

1 reference

Impact of novel screening technologies on ion channel drug discovery

21 January 2018

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Screening technologies for ion channel drug discovery

21 January 2018

1 reference

Atomic absorption spectroscopy in ion channel screening

21 January 2018

1 reference

Inhibition of N-methyl-D-aspartate evoked sodium flux by MK-801.

21 January 2018

1 reference

Synthesis and pharmacological evaluation of 2, 3-dihydro-3-oxo-4H-thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxides as voltage-dependent calcium channel blockers.

21 January 2018

1 reference

Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

21 January 2018

1 reference

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists

21 January 2018

1 reference

High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.

21 January 2018

1 reference

Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

21 January 2018

1 reference

Automated electrophysiology in drug discovery

21 January 2018

1 reference

State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format

21 January 2018

1 reference

Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels

21 January 2018

1 reference

The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.

21 January 2018

1 reference

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

21 January 2018

1 reference

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

21 January 2018

1 reference

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

21 January 2018

1 reference

Age-dependent alteration of the serum-unbound fraction of nicardipine, a calcium-channel blocker, in man.

21 January 2018

1 reference

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

21 January 2018

1 reference

An automated electrophysiology serum shift assay for K(V) channels

21 January 2018

1 reference

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.

21 January 2018

1 reference

Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods

21 January 2018

1 reference

Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.

21 January 2018

1 reference

α4β2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of α4β2 nAChR agonists in pain

21 January 2018

1 reference

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist

21 January 2018

1 reference

Alternative splicing matters: N-type calcium channels in nociceptors

21 January 2018

1 reference

Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy

21 January 2018

1 reference

A radioactive uptake assay to measure ion transport across ion channel-containing liposomes.

21 January 2018

1 reference

Planar patch clamp approach to characterize ionic currents from intact lysosomes.

21 January 2018

1 reference

Transsynaptic channelosomes: non-conducting roles of ion channels in synapse formation

21 January 2018

1 reference

Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells

21 January 2018

1 reference

Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons

21 January 2018

1 reference

Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes

21 January 2018

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In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

21 January 2018

1 reference

Human embryonic stem cells: current technologies and emerging industrial applications.

21 January 2018

1 reference

The application of human embryonic stem cell technologies to drug discovery

21 January 2018

1 reference

Embryonic stem cells as a novel cell source of cell-based biosensors

21 January 2018

1 reference

Cardiac stem/progenitor cells, secreted proteins, and proteomics

21 January 2018

1 reference

Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening.

21 January 2018

1 reference

High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type glutamate receptors

21 January 2018

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Can human embryonic stem cells contribute to the discovery of safer and more effective drugs?

21 January 2018

1 reference

Combination of functional cardiomyocytes derived from human stem cells and a highly-efficient microelectrode array system: an ideal hybrid model assay for drug development

21 January 2018

1 reference

Human embryonic stem cell technologies and drug discovery

21 January 2018

1 reference

Human embryonic stem cells for cardiomyogenesis

21 January 2018

1 reference

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

21 January 2018

1 reference

Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment

21 January 2018

1 reference

Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen

21 January 2018

1 reference

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen

21 January 2018

1 reference

A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation

21 January 2018

1 reference

STIM1, an essential and conserved component of store-operated Ca2+ channel function

21 January 2018

1 reference

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

21 January 2018

1 reference

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

21 January 2018

1 reference

Novel trends in high-throughput screening

21 January 2018

1 reference

Natural products and ion channel pharmacology

21 January 2018

1 reference

Natural products in drug discovery: present status and perspectives

21 January 2018

1 reference

Natural products in drug discovery

21 January 2018

1 reference

Drug development from marine natural products

21 January 2018

1 reference

Venomics as a drug discovery platform

21 January 2018

1 reference

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

21 January 2018

1 reference

1990-2010: two decades of interferon-based therapy

21 January 2018

1 reference

Specific antibodies to the external vestibule of voltage-gated potassium channels block current

21 January 2018

1 reference

Generation of functional ion-channel tools by E3 targeting.

21 January 2018

1 reference

Production of a specific extracellular inhibitor of TRPM3 channels.

21 January 2018

1 reference

A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation.

21 January 2018

1 reference

Structure-aided drug design's next generation

21 January 2018

1 reference

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

Structure based evolution of a novel series of positive modulators of the AMPA receptor

21 January 2018

1 reference

Understanding ion channels using computational approaches

21 January 2018

1 reference

Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies

21 January 2018

1 reference

Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled trial, N01C3.

21 January 2018

1 reference

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker se

21 January 2018

1 reference

The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

21 January 2018

1 reference

Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia

21 January 2018

1 reference

Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine

21 January 2018

1 reference

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

Translational PK-PD modelling of molecular target modulation for the AMPA receptor positive allosteric modulator Org 26576.

21 January 2018

1 reference

Open innovation networks between academia and industry: an imperative for breakthrough therapies

21 January 2018

1 reference

Challenges for and current status of research into positive modulators of AMPA receptors.

21 January 2018

1 reference

Pharmacotherapy of epilepsy: newly approved and developmental agents

21 January 2018

1 reference

Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.12.4

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release_qiuwxbtomra5pjuxdyjaenebq4

26 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qiuwxbtomra5pjuxdyjaenebq4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference