(Q37999102)

26 August 2017

Cyclotides as a basis for drug design (English)

1 reference

26 August 2017

1

1 reference

26 August 2017

Joakim E Swedberg

2

0 references

Joshua S. Mylne

object named as

Joshua S Mylne

series ordinal

3

0 references

author name string

Masa Cemazar

series ordinal

4

1 reference

PubMed ID

22468950

26 August 2017

language of work or name

English

0 references

publication date

21 February 2012

1 reference

Expert Opinion on Drug Discovery

26 August 2017

1 reference

26 August 2017

7

1 reference

26 August 2017

3

1 reference

26 August 2017

179-194

1 reference

Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Seven novel macrocyclic polypeptides from Viola arvensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Twists, knots, and rings in proteins. Structural definition of the cyclotide framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Discovery of an unusual biosynthetic origin for circular proteins in legumes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biosynthesis of circular proteins in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

An asparaginyl endopeptidase mediates in vivo protein backbone cyclization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The cyclotide family of circular miniproteins: nature's combinatorial peptide template.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cytotoxic cyclotides from Viola tricolor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Circling the enemy: cyclic proteins in plant defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Insecticidal plant cyclotides and related cystine knot toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The anthelmintic activity of the cyclotides: natural variants with enhanced activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

A Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Converting a peptide into a drug: strategies to improve stability and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

A biomimetic strategy in the synthesis and fragmentation of cyclic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Chemical synthesis and biosynthesis of the cyclotide family of circular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Oxidative folding of the cystine knot motif in cyclotide proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Plant cell culture technology-harnessing a biological approach for competitive cyclotides production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Progress in kalata peptide production via plant cell bioprocessing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclotide synthesis and supply: from plant to bioprocess

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Plant cell-based processes for cyclotides production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biosynthesis of a fully functional cyclotide inside living bacterial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclotides, a promising molecular scaffold for peptide-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Novel strategies for isolation and characterization of cyclotides: the discovery of bioactive macrocyclic plant polypeptides in the Violaceae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Isolation, sequencing, and structure-activity relationships of cyclotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The chemistry of cyclotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

NMR as a tool for elucidating the structures of circular and knotted proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Squash inhibitors: from structural motifs to macrocyclic knottins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Bioactive cystine knot proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclotides as templates in drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclotides: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Acyclic permutants of naturally occurring cyclic proteins. Characterization of cystine knot and beta-sheet formation in the macrocyclic polypeptide kalata B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Retrocyclins: using past as prologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Knottin cyclization: impact on structure and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Update 1 of: Proteases universally recognize beta strands in their active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Evolution of primate theta-defensins: a serpentine path to a sweet tooth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Reawakening retrocyclins: ancestral human defensins active against HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Retrocyclins and their activity against HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Chemistry. Seamless proteins tie up their loose ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Naturally occurring circular proteins: distribution, biosynthesis and evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Peptide AS-48: prototype of a new class of cyclic bacteriocins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Circular proteins--no end in sight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

New circulin macrocyclic polypeptides from Chassalia parvifolia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Cycloviolins A-D, anti-HIV macrocyclic peptides from Leonia cymosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

A novel anti-HIV macrocyclic peptide from Palicourea condensata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Isolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Distribution and evolution of circular miniproteins in flowering plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.661554

10.1517/17460441.2012.661554

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22468950