(Q38000159)

26 August 2017

NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death (English)

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26 August 2017

protein ubiquitination

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1 reference

Marie Anne O'Donnell

1

1 reference

PubMed ID

22477525

26 August 2017

Adrian T Ting

series ordinal

2

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26 August 2017

1 December 2012

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26 August 2017

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26 August 2017

54

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26 August 2017

1-3

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26 August 2017

214-226

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https://scigraph.springernature.com/pub.10.1007/s12026-012-8321-7

26 August 2017

0 references

cites work

Function and activation of NF-kappa B in the immune system

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The yins of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Regulation and function of NF-kappaB transcription factors in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Regulation and function of IKK and IKK-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Hierarchies of NF-κB target-gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Substrate targeting in the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Constructing and decoding unconventional ubiquitin chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Essential role for IKKgamma/NEMO in TCR-induced IL-2 expression in Jurkat T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The anti-death machinery in IKK/NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Regulated commitment of TNF receptor signaling: a molecular switch for death or activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Antigen-mediated T cell expansion regulated by parallel pathways of death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

NF-kappaB protects macrophages from lipopolysaccharide-induced cell death: the role of caspase 8 and receptor-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Immunogenic and tolerogenic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Non-canonical inflammasome activation targets caspase-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Mincle is an ITAM-coupled activating receptor that senses damaged cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

RIP kinases at the crossroads of cell death and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Deubiquitylation and regulation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

TNFalpha-induced macrophage death via caspase-dependent and independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Functional dichotomy of A20 in apoptotic and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Shigella targets the mitochondrial checkpoint of programmed necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8321-7

A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes

21 January 2018

1 reference

12 December 2020

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

1 reference

12 December 2020

Mechanisms of necroptosis in T cells

1 reference

12 December 2020

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

1 reference

12 December 2020

Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product

1 reference

12 December 2020

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

1 reference

12 December 2020

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

1 reference

12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

12 December 2020

Decoding cell death signals in inflammation and immunity

1 reference

12 December 2020

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements

1 reference

12 December 2020

10.1007/S12026-012-8321-7

Identifiers

DOI

1 reference

PubMed ID

22477525

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22477525