(Q38000483)

26 August 2017

title

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications (English)

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26 August 2017

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2

Michael Sperling

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26 August 2017

1

Björn Meermann

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26 August 2017

language of work or name

English

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publication date

6 April 2012

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Analytical and Bioanalytical Chemistry

26 August 2017

number of pages

22

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based on heuristic

inferred from page(s)

published in

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26 August 2017

volume

403

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26 August 2017

issue

6

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26 August 2017

page(s)

1501-1522

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Metal based drugs: from serendipity to design

26 August 2017

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Direct comparison of capillary electrophoresis and capillary liquid chromatography hyphenated to collision-cell inductively coupled plasma mass spectrometry for the investigation of Cd-, Cu- and Zn-containing metalloproteins

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Hyphenation and hypernation the practice and prospects of multiple hyphenation

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Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and s

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Mobile phase selection for the combined use of liquid chromatography-inductively coupled plasma mass spectrometry and electrospray ionisation mass spectrometry

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High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds

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Compensation of gradient related effects when using capillary liquid chromatography and inductively coupled plasma mass spectrometry for the absolute quantification of phosphorylated peptides

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The status of platinum anticancer drugs in the clinic and in clinical trials

21 January 2018

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Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity.

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Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy

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Drug transporters in chemotherapy induced peripheral neurotoxicity: current knowledge and clinical implications

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Platinum speciation used for elucidating activation or inhibition of Pt-containing anti-cancer drugs

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21 January 2018

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Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge

21 January 2018

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Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents

21 January 2018

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Evaluation of cisplatin and a novel platinum polymer conjugate for drug toxicity and drug distribution in mice

21 January 2018

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Speciation analysis of platinum antitumoral drugs in impacted tissues

21 January 2018

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Novel insights into the bottom-up mass spectrometry proteomics approach for the characterization of Pt-binding proteins: The insulin-cisplatin case study.

21 January 2018

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Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin.

21 January 2018

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A study of the interactions between carboplatin and blood plasma proteins using size exclusion chromatography coupled to inductively coupled plasma mass spectrometry

21 January 2018

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Mass spectrometric studies of cisplatin-induced changes of hemoglobin

21 January 2018

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Interaction of oxaliplatin, cisplatin, and carboplatin with hemoglobin and the resulting release of a heme group.

21 January 2018

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Speciation of oxaliplatin adducts with DNA nucleotides.

21 January 2018

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Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry.

21 January 2018

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Particular aspects of platinum compounds used at present in cancer treatment

21 January 2018

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Ruthenium antimetastatic agents

21 January 2018

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Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A.

21 January 2018

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Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis

21 January 2018

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Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins

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Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study

21 January 2018

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Pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia treated with arsenic trioxide

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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New delivery strategies for the old pentavalent antimonial drugs

21 January 2018

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Development of a reversed FIA system for the spectrophotometric determination of Sb(III) and total Sb in antileishmanial drugs

21 January 2018

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Speciation analysis of Sb(III) and Sb(V) in antileishmaniotic drug using Dowex 1 x 4 resin from hydrochloric acid solution

21 January 2018

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Novel Intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani.

21 January 2018

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Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs

21 January 2018

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21 January 2018

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Measurement of 'free' gold in patients receiving disodium aurothiomalate and the association of high free to total gold levels with toxicity

21 January 2018

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Gold compounds as therapeutic agents for human diseases

21 January 2018

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Gold derivatives for the treatment of cancer

21 January 2018

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Novel gold(I) phosphine compounds inhibit HIV-1 enzymes

21 January 2018

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HIV therapeutic possibilities of gold compounds

21 January 2018

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Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

21 January 2018

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Gold implants and increased expression of metallothionein-I/II as a novel hypothesized therapeutic approach for autism

21 January 2018

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Metallo–allixinate complexes with anti-diabetic and anti-metabolic syndrome activities

21 January 2018

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Bis(maltolato)vanadium(III)-polypyridyl complexes: synthesis, characterization, DNA cleavage, and insulin mimetic activity.

21 January 2018

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Study of the antidiabetic capacity of the VO(dmpp)2 complex.

21 January 2018

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Biospeciation of tungsten in the serum of diabetic and healthy rats treated with the antidiabetic agent sodium tungstate.

21 January 2018

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Study of tungstate-protein interaction in human serum by LC-ICP-MS and MALDI-TOF.

21 January 2018

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Vanadium treatment of type 2 diabetes: a view to the future

21 January 2018

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Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine

21 January 2018

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Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution

21 January 2018

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Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling--application to a novel antituberculosis compound as a case study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Quantification and excretion kinetics of a magnetic resonance imaging contrast agent by capillary electrophoresis-mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Chromatographic methods for the quantification of free and chelated gadolinium species in MRI contrast agent formulations

21 January 2018

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Determination of the MRI contrast agent Gd-DTPA by SEC-ICP-MS.

21 January 2018

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Analysis of the contrast agent Magnevist and its transmetalation products in blood plasma by capillary electrophoresis/electrospray ionization time-of-flight mass spectrometry

21 January 2018

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MRI-guided neutron capture therapy by use of a dual gadolinium/boron agent targeted at tumour cells through upregulated low-density lipoprotein transporters

21 January 2018

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Validation and use of three complementary analytical methods (LC-FLS, LC-MS/MS and ICP-MS) to evaluate the pharmacokinetics, biodistribution and stability of motexafin gadolinium in plasma and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

An electrospray/inductively coupled plasma dual-source time-of-flight mass spectrometer for rapid metallomic and speciation analysis. Part 1. Molecular channel characterization

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Determination of gold-based antiarthritis drugs and their metabolites in urine by reversed-phase ion-pair chromatography with ICP-MS detection

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Quantification of electrochemically generated iodine-containing metabolites using inductively coupled plasma mass spectrometry

21 January 2018

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Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography-inductively coupled plasma mass spectroscopy and quadrupole time-of-flight mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulations quality control

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Sequential determination of iron(II) and iron(III) in pharmaceutical by flow-injection analysis with spectrophotometric detection

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Determination of pentavalent antimony in antileishmaniotic drugs using an automated system for liquid-liquid extraction with on-line detection.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Speciation analysis, bioavailability and risk assessment of copper complexes in phytomedicines using flame atomic absorption spectrometry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Intravaginal toxicity studies of a gel-microemulsion formulation of spermicidal vanadocenes in rabbits

21 January 2018

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Efficient polyatomic interference reduction in plasma-source mass spectrometry via collision induced dissociation

21 January 2018

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Determination of Sb(III) and Total Sb in Antileishmanial Drugs by Spectrophotometric Flow‐Injection Hydride Generation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

Advantages and limitations of a desolvation system coupled online to HPLC-ICPqMS/ES-MS for the quantitative determination of sulfur and arsenic in arseno-peptide complexes

21 January 2018

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Recent progress in the application of analytical techniques to anticancer metallodrug proteomics

21 January 2018

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Optimisation of ICP-dynamic reaction cell-MS as specific detector for the speciation analysis of vanadium at therapeutic levels in serum

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00216-012-5915-9

10.1007/S00216-012-5915-9

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference