(Q38006576)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

12 December 2020

Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

2 references

12 December 2020

1 reference

1 reference

1

1 reference

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30 January 2020

4

Nicole P Juffermans

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

5

Marcus J Schultz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

author name string

Barry Dixon

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Marcel Levi

series ordinal

3

1 reference

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30 January 2020

publication date

12 December 2012

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

12 December 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

12 December 2020

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

page(s)

R70

1 reference

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Creative Commons Attribution 2.0 Generic

30 January 2020

copyright license

1 reference

https://scigraph.springernature.com/pub.10.1186/cc11325

12 December 2020

0 references

0 references

cites work

Coagulopathy as a therapeutic target for TRALI: rationale and possible sites of action

1 reference

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Drotrecogin alfa (activated)...a sad final fizzle to a roller-coaster party

6 September 2017

1 reference

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Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated).

6 September 2017

1 reference

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Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury

6 September 2017

1 reference

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Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial

6 September 2017

1 reference

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Inhaled activated protein C protects mice from ventilator-induced lung injury

6 September 2017

1 reference

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The bronchial circulation--worth a closer look: a review of the relationship between the bronchial vasculature and airway inflammation

6 September 2017

1 reference

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Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

6 September 2017

1 reference

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A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia

6 September 2017

1 reference

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Antithrombin III for critically ill patients

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Randomized clinical trial of activated protein C for the treatment of acute lung injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Aerosol delivery during mechanical ventilation: from basic techniques to new devices

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

A phase 1 trial of nebulised heparin in acute lung injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

The epithelium in acute lung injury/acute respiratory distress syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Pathophysiology of acute lung injury and the acute respiratory distress syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia--a review

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Anticoagulant therapy in acute lung injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Genetics of coagulation factors in acute lung injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Bacterial plasminogen activators and receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Anticoagulants for acute respiratory distress syndrome: can they work?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Efficacy and safety of recombinant human activated protein C for severe sepsis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

The acute respiratory distress syndrome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Diagnosis and treatment of smoke inhalation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Protein C and thrombomodulin in human acute lung injury

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Massive alveolar thrombin activation in Pseudomonas aeruginosa-induced acute lung injury

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Effects of heparin and lisofylline on pulmonary function after smoke inhalation injury in an ovine model

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

Antibiotic penetration in the respiratory tract and implications for the selection of antimicrobial therapy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681399

The role of heparin and allied compounds in the treatment of sepsis

31 August 2018

1 reference

12 December 2020

In vivo effect of adhesion inhibitor heparin on Legionella pneumophila pathogenesis in a murine pneumonia model

1 reference

12 December 2020

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)

1 reference

12 December 2020

A breathtaking and bloodcurdling story of coagulation and inflammation in acute lung injury

1 reference

12 December 2020

Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury

1 reference

12 December 2020

Alveolar Fibrin Formation Caused by Enhanced Procoagulant and Depressed Fibrinolytic Capacities in Severe Pneumonia

1 reference

12 December 2020

Antithrombin III in patients with severe sepsis. A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin III in severe sepsis

1 reference

12 December 2020

Disseminated intravascular coagulation

1 reference

12 December 2020

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment*

1 reference

12 December 2020

Inhaled activated protein C attenuates lung injury induced by aerosolized endotoxin in mice

1 reference

12 December 2020

Identifiers

DOI

10.1186/CC11325

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22546487

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22546487%20AND%20SRC:MED&resulttype=core&format=json