(Q38007828)

26 August 2017

title

The airway epithelium in asthma. (English)

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26 August 2017

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Hamida Hammad

2

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Bart Lambrecht

series ordinal

1

object named as

Bart N Lambrecht

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26 August 2017

language of work or name

English

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publication date

4 May 2012

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26 August 2017

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26 August 2017

volume

18

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26 August 2017

issue

5

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26 August 2017

page(s)

684-692

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Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

26 August 2017

cites work

1 reference

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Functions of T cells in asthma: more than just T(H)2 cells.

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T-helper type 2-driven inflammation defines major subphenotypes of asthma.

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A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

21 January 2018

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Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization.

21 January 2018

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Defective epithelial barrier function in asthma.

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Biology of lung dendritic cells at the origin of asthma

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A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins

21 January 2018

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Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology

21 January 2018

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Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

21 January 2018

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In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

21 January 2018

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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

21 January 2018

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TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen.

21 January 2018

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

21 January 2018

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Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.

21 January 2018

1 reference

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2

21 January 2018

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Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells.

21 January 2018

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Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin.

21 January 2018

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Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

21 January 2018

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Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

21 January 2018

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Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen

21 January 2018

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Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium

21 January 2018

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A20 regulation of nuclear factor-κB: perspectives for inflammatory lung disease

21 January 2018

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The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.

21 January 2018

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Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.

21 January 2018

1 reference

Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway disease.

21 January 2018

1 reference

Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways

21 January 2018

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Interleukin 12 p40 production by barrier epithelial cells during airway inflammation

21 January 2018

1 reference

Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs

21 January 2018

1 reference

Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells

21 January 2018

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IL-36R ligands are potent regulators of dendritic and T cells

21 January 2018

1 reference

IL-33-activated dendritic cells induce an atypical TH2-type response

21 January 2018

1 reference

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

21 January 2018

1 reference

Increased IL-33 expression by epithelial cells in bronchial asthma.

21 January 2018

1 reference

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells

21 January 2018

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Interleukin 25 promotes the initiation of proallergic type 2 responses.

21 January 2018

1 reference

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.

21 January 2018

1 reference

GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice

21 January 2018

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Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

21 January 2018

1 reference

Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism

21 January 2018

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Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF

21 January 2018

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Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation.

21 January 2018

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On the generation of allergic airway diseases: from GM-CSF to Kyoto.

21 January 2018

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Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity

21 January 2018

1 reference

Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma

21 January 2018

1 reference

Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2

21 January 2018

1 reference

Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin

21 January 2018

1 reference

Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation

21 January 2018

1 reference

Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice

21 January 2018

1 reference

IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo

21 January 2018

1 reference

IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production

21 January 2018

1 reference

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

21 January 2018

1 reference

IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses

21 January 2018

1 reference

TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

21 January 2018

1 reference

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity.

21 January 2018

1 reference

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

21 January 2018

1 reference

Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism.

21 January 2018

1 reference

Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells

21 January 2018

1 reference

IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease

21 January 2018

1 reference

An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

21 January 2018

1 reference

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

21 January 2018

1 reference

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

21 January 2018

1 reference

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

21 January 2018

1 reference

Epithelial, dendritic, and CD4(+) T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization.

21 January 2018

1 reference

HIF‐1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium

21 January 2018

1 reference

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

21 January 2018

1 reference

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

21 January 2018

1 reference

Role of hyaluronan and hyaluronan-binding proteins in human asthma

21 January 2018

1 reference

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

21 January 2018

1 reference

Endogenous attenuation of allergic lung inflammation by syndecan-1.

21 January 2018

1 reference

IL-37 is a fundamental inhibitor of innate immunity

21 January 2018

1 reference

Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease

21 January 2018

1 reference

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

21 January 2018

1 reference

Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects

21 January 2018

1 reference

Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.

21 January 2018

1 reference

E-cadherin: gatekeeper of airway mucosa and allergic sensitization

21 January 2018

1 reference

Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

21 January 2018

1 reference

Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity.

21 January 2018

1 reference

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness

21 January 2018

1 reference

Cockroach extract antigen increases bronchial airway epithelial permeability

21 January 2018

1 reference

Pollen proteolytic enzymes degrade tight junctions

21 January 2018

1 reference

The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model.

21 January 2018

1 reference

Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro

21 January 2018

1 reference

Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells

21 January 2018

1 reference

Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction

21 January 2018

1 reference

Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions.

21 January 2018

1 reference

Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

21 January 2018

1 reference

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma.

21 January 2018

1 reference

Epithelial-mesenchymal interactions in the pathogenesis of asthma

21 January 2018

1 reference

Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma

21 January 2018

1 reference

Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling

21 January 2018

1 reference

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

21 January 2018

1 reference

Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling

21 January 2018

1 reference

Lung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 years.

21 January 2018

1 reference

Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution

21 January 2018

1 reference

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

21 January 2018

1 reference

Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack

21 January 2018

1 reference

Interleukin-13: central mediator of allergic asthma

21 January 2018

1 reference

Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells

21 January 2018

1 reference

The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium

21 January 2018

1 reference

Changes in the mucosal barrier during acute and chronic Trichuris muris infection.

21 January 2018

1 reference

CD11c depletion severely disrupts Th2 induction and development in vivo

21 January 2018

1 reference

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

1 reference

Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.

21 January 2018

1 reference

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

21 January 2018

1 reference

Role of viral respiratory infections in asthma and asthma exacerbations

21 January 2018

1 reference

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

21 January 2018

1 reference

IL-13 suppresses double-stranded RNA-induced IFN-λ production in lung cells

21 January 2018

1 reference

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

21 January 2018

1 reference

HMGB1 interacts differentially with members of the Rel family of transcription factors

21 January 2018

1 reference

Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.

21 January 2018

1 reference

Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17.

21 January 2018

1 reference

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

21 January 2018

1 reference

Toll-like receptor-9 agonist inhibits airway inflammation, remodeling and hyperreactivity in mice exposed to chronic environmental tobacco smoke and allergen

21 January 2018

1 reference

Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.

21 January 2018

1 reference

Activation of airway epithelial cells by toll-like receptor agonists

21 January 2018

1 reference

Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouse

21 January 2018

1 reference

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

21 January 2018

1 reference

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice

21 January 2018

1 reference

NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation.

21 January 2018

1 reference

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

21 January 2018

1 reference

The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism

21 January 2018

1 reference

Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment

21 January 2018

1 reference

Interactions between inhalant allergen extracts and airway epithelial cells: effect on cytokine production and cell detachment

21 January 2018

1 reference

Mucosal sensitization to German cockroach involves protease-activated receptor-2.

21 January 2018

1 reference

Intersections between pulmonary development and disease

21 January 2018

1 reference

Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury

21 January 2018

1 reference

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma

21 January 2018

1 reference

SPDEF regulates goblet cell hyperplasia in the airway epithelium

21 January 2018

1 reference

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.

21 January 2018

1 reference

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation

21 January 2018

1 reference

NK Cell Deficiency Predisposes to Viral-Induced Th2-Type Allergic Inflammation via Epithelial-Derived IL-25

21 January 2018

1 reference

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

21 January 2018

1 reference

Role of deficient type III interferon-λ production in asthma exacerbations

21 January 2018

1 reference

Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma

21 January 2018

1 reference

12 December 2020

Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers

1 reference

12 December 2020

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

1 reference

12 December 2020

Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells

1 reference

12 December 2020

Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice

1 reference

12 December 2020

Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma

1 reference

12 December 2020

Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation

1 reference

12 December 2020

Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

1 reference

12 December 2020

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

1 reference

12 December 2020

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

12 December 2020

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

1 reference

12 December 2020

beta-Glucans in standardized allergen extracts

1 reference

12 December 2020

IL-33-activated dendritic cells are critical for allergic airway inflammation

1 reference

12 December 2020

Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway

1 reference

12 December 2020

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

1 reference

12 December 2020

Foxa2 programs Th2 cell-mediated innate immunity in the developing lung

1 reference

12 December 2020

Trefoil factor 2 regulates airway remodeling in animal models of asthma

1 reference

12 December 2020

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

1 reference

12 December 2020

A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma

1 reference

12 December 2020

IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2737

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26 August 2017

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