(Q38008726)

26 August 2017

title

Heat shock proteins in cancer: targeting the 'chaperones'. (English)

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26 August 2017

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Z Nahleh

1

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26 August 2017

A Tfayli

2

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26 August 2017

A Najm

3

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26 August 2017

A El Sayed

4

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26 August 2017

Z Nahle

5

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26 August 2017

publication date

1 May 2012

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Future Medicinal Chemistry

26 August 2017

published in

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26 August 2017

volume

4

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26 August 2017

issue

7

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26 August 2017

page(s)

927-935

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The heat shock response: life on the verge of death

26 August 2017

cites work

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Pathways of chaperone-mediated protein folding in the cytosol

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Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response

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Heat shock proteins as emerging therapeutic targets

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Hsp70 and Hsp90--a relay team for protein folding

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Structure and mechanism of the Hsp90 molecular chaperone machinery

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Hsp27 negatively regulates cell death by interacting with cytochrome c.

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Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

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Heat-shock protein 70 antagonizes apoptosis-inducing factor

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Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27

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The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70.

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Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector. Influences of overexpression of HSP90 protein on high temperature growth and thermotolerance

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Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins.

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Aging and molecular chaperones

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Inflammation, heat shock proteins, and type 2 diabetes

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Heat shock proteins in animal neoplasms and human tumours--a comparison

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Heat shock proteins: a potential anticancer target

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Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

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Heat shock proteins in cancer: chaperones of tumorigenesis

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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Heat shock cognate protein 70 is essential for Akt signaling in endothelial function

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Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review

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Heat-shock proteins as regulators of apoptosis

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Targeting the dynamic HSP90 complex in cancer

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Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

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HSP90 and the chaperoning of cancer

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High HSP90 expression is associated with decreased survival in breast cancer

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The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

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Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells

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A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas

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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

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21 January 2018

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NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

21 January 2018

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SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

21 January 2018

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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

21 January 2018

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More than folding: localized functions of cytosolic chaperones

21 January 2018

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A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

21 January 2018

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Targeting HSP70 for cancer therapy.

21 January 2018

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Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer

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21 January 2018

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Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications

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Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

21 January 2018

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Death by chaperone: HSP90, HSP70 or both?

21 January 2018

1 reference

HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation

21 January 2018

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Analysis of differential protein expression in normal and neoplastic human breast epithelial cell lines

21 January 2018

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Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells

21 January 2018

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Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells.

21 January 2018

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Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

21 January 2018

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Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges

21 January 2018

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Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.

21 January 2018

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Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer.

21 January 2018

1 reference

Protein kinase A binds and activates heat shock factor 1

21 January 2018

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Heat shock factors: integrators of cell stress, development and lifespan.

21 January 2018

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Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

21 January 2018

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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.

21 January 2018

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Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.

21 January 2018

1 reference

Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.12.50

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26 August 2017

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