(Q38009992)

26 August 2017

Olfactory dysfunction in Parkinson disease (English)

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26 August 2017

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1

Richard L Doty

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PubMed ID

22584158

26 August 2017

language of work or name

English

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publication date

15 May 2012

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26 August 2017

Nature Reviews Neurology

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26 August 2017

8

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26 August 2017

6

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26 August 2017

329-339

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2012.80

26 August 2017

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Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease.

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Olfactory function in atypical parkinsonian syndromes

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Lack of major olfactory dysfunction in MPTP-induced parkinsonism

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Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy

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Olfactory function in essential tremor

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Olfactory tests in the diagnosis of essential tremor

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The olfactory and cognitive deficits of Parkinson's disease: evidence for independence

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Loss of olfaction in de novo and treated Parkinson's disease: possible implications for early diagnosis

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Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease

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Cognition and olfaction in Parkinson's disease.

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Olfactory deficits and cognitive dysfunction in Parkinson's disease.

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A comparative study of odor identification and odor discrimination deficits in Parkinson's disease

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Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results

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Effect of short and long term STN stimulation periods on parkinsonian signs

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[99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease.

31 March 2020

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Motor and non-motor correlates of olfactory dysfunction in Parkinson's disease.

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Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity

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Association of anosmia with autonomic failure in Parkinson disease

31 March 2020

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Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy.

31 March 2020

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Association of olfactory dysfunction with risk for future Parkinson's disease

31 March 2020

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Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT).

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Smell identification ability in twin pairs discordant for Parkinson's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Abnormal performance on the PD test battery by asymptomatic first-degree relatives.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Idiopathic hyposmia as a preclinical sign of Parkinson's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study.

31 March 2020

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Parkinson disease in twins: an etiologic study

31 March 2020

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Validity of family history data on PD: evidence for a family information bias

31 March 2020

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Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.

31 March 2020

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Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory dysfunction in LRRK2 G2019S mutation carriers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Subclinical signs in LRRK2 mutation carriers.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory function in Huntington's disease patients and at-risk offspring

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Stages in the development of Parkinson's disease-related pathology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The anterior olfactory nucleus in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Regional differences in the severity of Lewy body pathology across the olfactory cortex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The olfactory vector hypothesis of neurodegenerative disease: is it viable?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Tau protein: relevance to Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Immunohistochemical analyses of the human olfactory bulb.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The nucleus basalis of Meynert in neurological disease: a quantitative morphological study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Autoimmune pathology accounts for common manifestations in a wide range of neuro-psychiatric disorders: the olfactory and immune system interrelationship

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Up-regulation of tyrosine hydroxylase mRNA in a sub-population of A10 dopamine neurons in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Dopaminergic and cholinergic lesions in progressive supranuclear palsy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory loss and nigrostriatal dopaminergic denervation in the elderly

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Where does parkinson disease pathology begin in the brain?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Effects of intrabulbar injections of 6-hydroxydopamine on ethyl acetate odor detection in castrate and non-castrate male rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

A cross-sectional study contrasting olfactory function in autonomic disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Noradrenergic regulation of inflammatory gene expression in brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Clonidine suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced reductions of striatal dopamine and tyrosine hydroxylase activity in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Serotonergic modulation of odor input to the mammalian olfactory bulb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The serotonergic system in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory disturbance induced by deafferentation of serotonergic fibers in the olfactory bulb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Bulbar Morphology and Expression of Bulbar Dopamine and Parvalbumin in Experimentally-induced Anosmic Rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Microglia-neuron interaction in inflammatory and degenerative diseases: role of cholinergic and noradrenergic systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Genetic and environmental influences on odor identification ability in the very old.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Smell identification ability: changes with age.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory dysfunction in patients with head trauma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Urban air pollution: influences on olfactory function and pathology in exposed children and young adults.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Detection of parainfluenza virus 3 in turbinate epithelial cells of postviral olfactory dysfunction patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory toxicity: long-term effects of occupational exposures.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Anterior distribution of human olfactory epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Odor identification ability and self-reported upper respiratory symptoms in workers at the post-9/11 World Trade Center site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

San Francisco/Oakland Bay Bridge Welder Study: olfactory function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory uptake of manganese requires DMT1 and is enhanced by anemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Effect of dietary iron-deficiency on the disposition of nickel in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The neuropathology of manganese-induced Parkinsonism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Postencephalitic parkinsonism--a review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Selective lesions of neural pathways following viral inoculation of the olfactory bulb.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Office procedures for quantitative assessment of olfactory function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Modern psychophysical tests to assess olfactory function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory functions in Parkinson's disease and Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

'Sniffin' sticks': olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The odor stick identification test for Japanese differentiates Parkinson's disease from multiple system atrophy and progressive supra nuclear palsy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Applicability of the cross-culturally modified University of Pennsylvania Smell Identification Test in a Japanese population

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory threshold in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Influences of age and sex on a microencapsulated odor memory test

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory dysfunction in familial parkinsonism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Olfactory heterogeneity in LRRK2 related Parkinsonism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations

31 March 2020

1 reference

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Gaucher disease ascertained through a Parkinson's center: imaging and clinical characterization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.80

Milestones in Parkinson's disease--clinical and pathologic features

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Olfactory system pathology as a model of Lewy neurodegenerative disease

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12 December 2020

Odor identification deficit of the parkinsonism-dementia complex of Guam: equivalence to that of Alzheimer's and idiopathic Parkinson's disease

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12 December 2020

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Olfactory dysfunction in Parkinsonism caused byPINK1mutations

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Identifiers

DOI

10.1038/NRNEUROL.2012.80

1 reference

PubMed ID

22584158

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22584158