(Q38010342)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

5

1 reference

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1 February 2020

4

Meindert Danhof

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Joost Westerhout

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Bart Ploeger

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Jean Smeets

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

language of work or name

English

0 references

publication date

17 May 2012

1 reference

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1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

543-553

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.

1 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Drug transport in brain via the cerebrospinal fluid

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Assessment of the blood-brain barrier in CNS drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Assays to predict drug permeation across the blood-brain barrier, and distribution to brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

CSF as a surrogate for assessing CNS exposure: an industrial perspective

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Progress in brain penetration evaluation in drug discovery and development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

On the rate and extent of drug delivery to the brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Drug development for CNS disorders: strategies for balancing risk and reducing attrition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

How to measure drug transport across the blood-brain barrier

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Water homeostasis in the brain: basic concepts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

The determination of plasma volume in man with radioactive chromic chloride

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Assessment of blood-brain barrier penetration: in silico, in vitro and in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Large CSF volume not attributable to ventricular volume in schizotypal personality disorder

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Efflux of radiolabeled polyethylene glycols and albumin from rat brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Physiology of the choroid plexus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Developmental defects of the cisterna magna and dura mater

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Metabolism of 3H-dopamine continuously perfused through push-pull cannulas in rats' brains: modification by amphetamine or prostaglandin F2 alpha

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

The cerebral ventricles of the rat

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: Clearance of carboxyl-[14C]inulin after intrathecal infusion

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Use of magnetic resonance imaging to measure intracranial cerebrospinal fluid volume

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Quantitative microdialysis: analysis of transients and application to pharmacokinetics in brain

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

The internal reference technique in microdialysis: A practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Potassium exchange between cerebrospinal fluid, plasma, and brain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

Analysis of brain and cerebrospinal fluid volumes with MR imaging. Part I. Methods, reliability, and validation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385827

31 August 2018

The mega cisterna magna

1 reference

12 December 2020

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier

1 reference

12 December 2020

Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

1 reference

12 December 2020

Blood volume in the rat

1 reference

12 December 2020

Effect of altering cerebrospinal fluid pressure on spinal cord blood flow

1 reference

12 December 2020

A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron

1 reference

12 December 2020

A rapid and simple cannulation technique for repeated sampling of cerebrospinal fluid in freely moving rats

1 reference

12 December 2020

Glucuronidation and biliary excretion of acetaminophen in rats

1 reference

12 December 2020

Biliary excretion and enterohepatic circulation of paracetamol in the rat

1 reference

12 December 2020

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

1 reference

12 December 2020

Microdialysis probes calibration: gradient and tissue dependent changes in no net flux and reverse dialysis methods

1 reference

12 December 2020

The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system

1 reference

12 December 2020

The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid

1 reference

12 December 2020

10.1208/S12248-012-9366-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22588644

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22588644%20AND%20SRC:MED&resulttype=core&format=json