(Q38010861)

26 August 2017

Expanding the chemical palate of cells by combining systems biology and metabolic engineering. (English)

1 reference

26 August 2017

Kathleen A Curran

1

1 reference

PubMed ID

22595280

26 August 2017

Hal S Alper

series ordinal

2

1 reference

26 August 2017

2 May 2012

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26 August 2017

Metabolic Engineering

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26 August 2017

14

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26 August 2017

289-297

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26 August 2017

4

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Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli

26 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composition in recombinant Salmonella enterica serovar typhimurium.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Tuning genetic control through promoter engineering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Uncovering the gene knockout landscape for improved lycopene production in E. coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for 1-butanol production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Toward a science of metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Investigations into viomycin biosynthesis by using heterologous production in Streptomyces lividans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Application of metabolic engineering to improve both the production and use of biotech indigo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Systems metabolic engineering: genome-scale models and beyond.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Improved vanillin production in baker's yeast through in silico design.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A retrosynthetic biology approach to metabolic pathway design for therapeutic production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Thermobifida fusca for direct aerobic bioconversion of untreated lignocellulosic biomass to 1-propanol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Further developments towards a genome-scale metabolic model of yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Fumaric acid production by fermentation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Improving lycopene production in Escherichia coli by engineering metabolic control.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

In silico design and adaptive evolution of Escherichia coli for production of lactic acid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

An engineered yeast efficiently secreting penicillin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Engineered synthetic pathway for isopropanol production in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Exploring the diversity of complex metabolic networks.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

High-throughput generation, optimization and analysis of genome-scale metabolic models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

In silico prediction and validation of the importance of the Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Multiple high-throughput analyses monitor the response of E. coli to perturbations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Mass action stoichiometric simulation models: incorporating kinetics and regulation into stoichiometric models.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

TIGER: Toolbox for integrating genome-scale metabolic models, expression data, and transcriptional regulatory networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

De novo computational design of retro-aldol enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Deciphering the late biosynthetic steps of antimalarial compound FR-900098.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microdiesel: Escherichia coli engineered for fuel production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microbial production of building block chemicals and polymers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Systems metabolic engineering of Escherichia coli for L-threonine production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Dynamic metabolic flux analysis (DMFA): a framework for determining fluxes at metabolic non-steady state.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Construction of stress-induced metabolic pathway from glucose to 1,3-propanediol in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Systems biology approach to integrative comparative genomics.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Quantitative analysis and engineering of fatty acid biosynthesis in E. coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Complete reconstitution of a highly reducing iterative polyketide synthase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Styrene biosynthesis from glucose by engineered E. coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for the production of malic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Production of glucaric acid from a synthetic pathway in recombinant Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering for the microbial production of 1,3-propanediol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Benzene-free synthesis of adipic acid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Constraints-based genome-scale metabolic simulation for systems metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

MILANO--custom annotation of microarray results using automatic literature searches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Identification and microbial production of a terpene-based advanced biofuel.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

OptStrain: a computational framework for redesign of microbial production systems.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Functional expression of prokaryotic and eukaryotic genes in Escherichia coli for conversion of glucose to p-hydroxystyrene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microbial 1-butanol production: Identification of non-native production routes and in silico engineering interventions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Targeted proteomics for metabolic pathway optimization: application to terpene production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Assemblage of ortho cleavage route for simultaneous degradation of chloro- and methylaromatics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microbial biosynthesis of alkanes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Analysis of optimality in natural and perturbed metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Network rigidity and metabolic engineering in metabolite overproduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Minimal Escherichia coli cell for the most efficient production of ethanol from hexoses and pentoses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

An engineered microbial platform for direct biofuel production from brown macroalgae.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

A computational approach to design and evaluate enzymatic reaction pathways: application to 1-butanol production from pyruvate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Synthetic biology: tools to design, build, and optimize cellular processes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Metabolic engineering of microbial pathways for advanced biofuels production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

L-malate production by metabolically engineered Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Production of 3-hydroxypropionate homopolymer and poly(3-hydroxypropionate-co-4-hydroxybutyrate) copolymer by recombinant Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

Genetic improvement of Escherichia coli for ethanol production: chromosomal integration of Zymomonas mobilis genes encoding pyruvate decarboxylase and alcohol dehydrogenase II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2012.04.006

10.1016/J.YMBEN.2012.04.006

7 January 2021

based on heuristic

deduced from DOI

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22595280