(Q38011006)

26 August 2017

Maintaining differentiated cellular identity (English)

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26 August 2017

Johan Holmberg

1

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PubMed ID

22596319

26 August 2017

Thomas Perlmann

series ordinal

2

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26 August 2017

18 May 2012

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26 August 2017

Nature Reviews Genetics

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26 August 2017

13

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26 August 2017

429-439

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26 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrg3209

26 August 2017

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cites work

Viable offspring derived from fetal and adult mammalian cells

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Forcing cells to change lineages

21 January 2018

1 reference

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues

21 January 2018

1 reference

Nuclear reprogramming to a pluripotent state by three approaches

21 January 2018

1 reference

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

21 January 2018

1 reference

Epigenetic factors influencing resistance to nuclear reprogramming

21 January 2018

1 reference

Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma

21 January 2018

1 reference

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

1 reference

Metaplasia and transdifferentiation: from pure biology to the clinic

21 January 2018

1 reference

Cytoplasmic activation of human nuclear genes in stable heterocaryons

21 January 2018

1 reference

Plasticity of the differentiated state

21 January 2018

1 reference

Control of differentiation in heterokaryons and hybrids involving differentiation-defective myoblast variants

21 January 2018

1 reference

Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons

21 January 2018

1 reference

Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional

21 January 2018

1 reference

Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons

21 January 2018

1 reference

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

21 January 2018

1 reference

Differentiation requires continuous regulation

21 January 2018

1 reference

Expression of a single transfected cDNA converts fibroblasts to myoblasts

21 January 2018

1 reference

GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts

21 January 2018

1 reference

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

21 January 2018

1 reference

PRDM16 controls a brown fat/skeletal muscle switch

21 January 2018

1 reference

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

21 January 2018

1 reference

21 January 2018

1 reference

Identification of intrinsic determinants of midbrain dopamine neurons

21 January 2018

1 reference

Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells

21 January 2018

1 reference

Network motifs: theory and experimental approaches

21 January 2018

1 reference

Properties of developmental gene regulatory networks

21 January 2018

1 reference

Direct conversion of fibroblasts to functional neurons by defined factors

21 January 2018

1 reference

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

21 January 2018

1 reference

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

21 January 2018

1 reference

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

21 January 2018

1 reference

Direct conversion of human fibroblasts to dopaminergic neurons

21 January 2018

1 reference

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.

21 January 2018

1 reference

PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells

21 January 2018

1 reference

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

21 January 2018

1 reference

Regulatory logic of neuronal diversity: terminal selector genes and selector motifs.

21 January 2018

1 reference

A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans

21 January 2018

1 reference

The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron.

21 January 2018

1 reference

The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons

21 January 2018

1 reference

Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans.

21 January 2018

1 reference

Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3.

21 January 2018

1 reference

Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene.

21 January 2018

1 reference

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

21 January 2018

1 reference

Gene regulatory logic of dopamine neuron differentiation

21 January 2018

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Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity

21 January 2018

1 reference

How to make a mesodiencephalic dopaminergic neuron

21 January 2018

1 reference

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

21 January 2018

1 reference

Specification of neuronal identities by feedforward combinatorial coding

21 January 2018

1 reference

Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system

21 January 2018

1 reference

Site- and time-specific gene targeting in the mouse

21 January 2018

1 reference

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

21 January 2018

1 reference

Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells

21 January 2018

1 reference

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

21 January 2018

1 reference

Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation

21 January 2018

1 reference

Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion

21 January 2018

1 reference

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

21 January 2018

1 reference

DMRT1 prevents female reprogramming in the postnatal mammalian testis

21 January 2018

1 reference

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

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Reversion of B cell commitment upon loss of Pax5 expression

21 January 2018

1 reference

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

21 January 2018

1 reference

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

21 January 2018

1 reference

The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance

21 January 2018

1 reference

Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development

21 January 2018

1 reference

Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka

21 January 2018

1 reference

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

21 January 2018

1 reference

Stepwise reprogramming of B cells into macrophages

21 January 2018

1 reference

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

21 January 2018

1 reference

Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming.

21 January 2018

1 reference

Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.

21 January 2018

1 reference

Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

1 reference

Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency

21 January 2018

1 reference

Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity

21 January 2018

1 reference

Lmx1b is essential for the development of serotonergic neurons

21 January 2018

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Pet-1 is required across different stages of life to regulate serotonergic function.

21 January 2018

1 reference

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.

21 January 2018

1 reference

Foxa2 is required for the differentiation of pancreatic alpha-cells

21 January 2018

1 reference

The Foxa family of transcription factors in development and metabolism

21 January 2018

1 reference

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

1 reference

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

21 January 2018

1 reference

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

21 January 2018

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Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.

21 January 2018

1 reference

A gene complex controlling segmentation in Drosophila

21 January 2018

1 reference

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 January 2018

1 reference

Silencing chromatin: comparing modes and mechanisms

21 January 2018

1 reference

Non-coding RNAs as regulators of embryogenesis

21 January 2018

1 reference

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

1 reference

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

1 reference

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

1 reference

Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

1 reference

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

21 January 2018

1 reference

Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

1 reference

Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

1 reference

Polycomb group proteins: navigators of lineage pathways led astray in cancer

21 January 2018

1 reference

Cellular memory and dynamic regulation of polycomb group proteins

21 January 2018

1 reference

The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

1 reference

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination

21 January 2018

1 reference

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

1 reference

Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes

21 January 2018

1 reference

Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells

21 January 2018

1 reference

iPS cells produce viable mice through tetraploid complementation

21 January 2018

1 reference

Epigenetic memory in induced pluripotent stem cells

21 January 2018

1 reference

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

21 January 2018

1 reference

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

21 January 2018

1 reference

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

21 January 2018

1 reference

X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells

21 January 2018

1 reference

X chromosome dosage compensation: how mammals keep the balance

21 January 2018

1 reference

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

21 January 2018

1 reference

Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

21 January 2018

1 reference

Association of Foxp3 regulatory gene expression with graft-versus-host disease

21 January 2018

1 reference

Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration

21 January 2018

1 reference

Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia.

21 January 2018

1 reference

Mutations in NR4A2 associated with familial Parkinson disease

21 January 2018

1 reference

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

21 January 2018

1 reference

Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina

21 January 2018

1 reference

Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice

21 January 2018

1 reference

Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling.

21 January 2018

1 reference

Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9

21 January 2018

1 reference

Hybrid Cells Derived from Mouse and Man : Artificial Heterokaryons of Mammalian Cells from Different Species

21 January 2018

1 reference

Identification of genes expressed in C. elegans touch receptor neurons

21 January 2018

1 reference

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

21 January 2018

1 reference

Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming

21 January 2018

1 reference

Lmx1b, Pet-1, andNkx2.2Coordinately Specify Serotonergic Neurotransmitter Phenotype

31 March 2020

1 reference

Mechanisms of polycomb gene silencing: knowns and unknowns

31 March 2020

1 reference

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

31 March 2020

1 reference

GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line

31 March 2020

1 reference

12 December 2020

The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes

1 reference

12 December 2020

A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans

1 reference

12 December 2020

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

1 reference

12 December 2020

Changes in the cytochemical properties of erythrocyte nuclei reactivated by cell fusion

1 reference

12 December 2020

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

1 reference

12 December 2020

Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes.

1 reference

12 December 2020

The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles

1 reference

12 December 2020

Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG3209

1 reference

PubMed ID

22596319

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22596319