(Q38014563)

27 August 2017

Application of nitric oxide in drug discovery and development (English)

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27 August 2017

1 reference

Nathan S Bryan

1

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PubMed ID

22646983

27 August 2017

language of work or name

English

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publication date

25 August 2011

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Expert Opinion on Drug Discovery

27 August 2017

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27 August 2017

6

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27 August 2017

11

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27 August 2017

1139-1154

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Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

21 January 2018

The molecule of the year

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Beneficial actions of nitrates in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The L-arginine-nitric oxide pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Binding sites of nitric oxide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

New biomaterials for the sustained release of nitric oxide: past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

State of the art of cardiac surgery in patients with congenital heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Reducing implant-related infections: active release strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Heart preservation with celsior solution improved by the addition of nitroglycerine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Organic nitrates and nitrate tolerance--state of the art and future developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Mechanisms of nitrate tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Differential expression of genes from nitrate-tolerant rat aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Prevention and reversal of nitrate tolerance in patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Dietary supplement with vitamin C prevents nitrate tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The effect of supplemental L-arginine on tolerance development during continuous transdermal nitroglycerin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Progress toward clinical application of the nitric oxide-releasing diazeniumdiolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Controlled photochemical release of nitric oxide from O2-substituted diazeniumdiolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide-releasing NSAIDs: a review of their current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The therapeutic potential of NO-NSAIDs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide and cyclic GMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Human recombinant soluble guanylyl cyclase: expression, purification, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Discovery of the nitric oxide signaling pathway and targets for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Phosphodiesterases and cyclic nucleotide signaling in endocrine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrosylation. the prototypic redox-based signaling mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

S-Nitrosothiols: cellular formation and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

The mechanism of transmembrane S-nitrosothiol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

S-nitrosylation in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Protein S-nitrosylation: purview and parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

NOS2 regulation of NF-kappaB by S-nitrosylation of p65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Protection from experimental asthma by an endogenous bronchodilator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Intragastric nitric oxide production in humans: measurements in expelled air.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrate, bacteria and human health

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrite in nitric oxide biology: cause or consequence? A systems-based review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrite in saliva increases gastric mucosal blood flow and mucus thickness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Effects of dietary nitrate on blood pressure in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide and mitochondrial signaling: from physiology to pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Food sources of nitrates and nitrites: the physiologic context for potential health benefits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Nitrate and nitrite in biology, nutrition and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

A Novel Reaction Mechanism for the Formation ofS-Nitrosothiolin Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.613933

10.1517/17460441.2011.613933

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22646983