(Q38014573)

27 August 2017

title

Peptide and peptoid foldamers in medicinal chemistry (English)

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27 August 2017

W Seth Horne

1

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27 August 2017

language of work or name

English

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publication date

2 November 2011

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

6

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27 August 2017

issue

12

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27 August 2017

page(s)

1247-1262

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Progress in modeling of protein structures and interactions

27 August 2017

cites work

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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A field guide to foldamers

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

β-Peptide Foldamers: Robust Helix Formation in a New Family of β-Amino Acid Oligomers

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Sequence-specific polypeptoids: a diverse family of heteropolymers with stable secondary structure

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Solid Phase Synthesis of beta-Peptoids: N-Substituted beta-Aminopropionic Acid Oligomers

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Foldamers with heterogeneous backbones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptoid-Peptide hybrid backbone architectures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

beta-Peptides: from structure to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Surprisingly stable helical conformations in alpha/beta-peptides by incorporation of cis-beta-aminocyclopropane carboxylic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Structural and Spectroscopic Studies of Peptoid Oligomers with α-Chiral Aliphatic Side Chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptoid architectures: elaboration, actuation, and application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Extraordinarily robust polyproline type I peptoid helices generated via the incorporation of α-chiral aromatic N-1-naphthylethyl side chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Kinetics and equilibria of cis/trans isomerization of backbone amide bonds in peptoids

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Oligo(N-aryl glycines): a new twist on structured peptoids.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2011.632002

New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptide hybrids containing alpha - and beta-amino acids: structure of a decapeptide beta-hairpin with two facing beta-phenylalanine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Toward beta-amino acid proteins: a cooperatively folded beta-peptide quaternary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

High-resolution structure of a beta-peptide bundle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Helix bundle quaternary structure from alpha/beta-peptide foldamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Folding a nonbiological polymer into a compact multihelical structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Antimicrobial peptides of multicellular organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Non-haemolytic beta-amino-acid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

De novo design, synthesis, and characterization of antimicrobial beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Antimicrobial 14-helical beta-peptides: potent bilayer disrupting agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Use of parallel synthesis to probe structure-activity relationships among 12-helical beta-peptides: evidence of a limit on antimicrobial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Unexpected relationships between structure and function in alpha,beta-peptides: antimicrobial foldamers with heterogeneous backbones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Bacterial species selective toxicity of two isomeric alpha/beta-peptides: role of membrane lipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Exploring the antibacterial and hemolytic activity of shorter- and longer-chain beta-, alpha,beta-, and gamma-peptides, and of beta-peptides from beta2-3-aza- and beta3-2-methylidene-amino acids bearing proteinogenic side chains--a survey.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Interplay among folding, sequence, and lipophilicity in the antibacterial and hemolytic activities of alpha/beta-peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Helical Peptoid Mimics of Magainin-2 Amide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Antimicrobial beta-peptoids by a block synthesis approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Novel lysine-peptoid hybrids with antibacterial properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Cell-penetrating peptides for drug delivery across membrane barriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Translocation of a beta-peptide across cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Cellular uptake studies with beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Chemical and Biological Investigations ofβ-Oligoarginines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Drug discovery and development for neglected parasitic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

New lead structures in antifungal drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Antifungal activity from 14-helical beta-peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Effect of sequence and structural properties on 14-helical beta-peptide activity against Candida albicans planktonic cells and biofilms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Polyelectrolyte multilayers fabricated from antifungal β-peptides: design of surfaces that exhibit antifungal activity against Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Biomimicry of surfactant protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Effects of hydrophobic helix length and side chain chemistry on biomimicry in peptoid analogues of SP-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Simple, helical peptoid analogs of lung surfactant protein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Fragments of the HIV-1 Tat protein specifically bind TAR RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptides containing membrane-transiting motifs inhibit virus entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Inhibition of herpes simplex virus type 1 infection by cationic beta-peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Transcription factors: structural families and principles of DNA recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Artificial chemokines: combining chemistry and molecular biology for the elucidation of interleukin-8 functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Opportunities in somatostatin research: biological, chemical and therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Synthesis and Biological Evaluation of a Cyclo-β-tetrapeptide as a Somatostatin Analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

p53 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Targeting protein-protein interactions: lessons from p53/MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Solution structure of a beta-peptide ligand for hDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Beta-peptides with improved affinity for hDM2 and hDMX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Cell-permeable beta-peptide inhibitors of p53/hDM2 complexation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

The HIV Env-mediated fusion reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Atomic structure of the ectodomain from HIV-1 gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Inhibiting HIV fusion with a beta-peptide foldamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Broad Distribution of Energetically Important Contacts across an Extended Protein Interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Structural and biological mimicry of protein surface recognition by / -peptide foldamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Coiled-coil domains in glycoproteins B and H are involved in human cytomegalovirus membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Rational development of beta-peptide inhibitors of human cytomegalovirus entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Computational design of a β-peptide that targets transmembrane helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Peptoids: a modular approach to drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Synthetic ligands discovered by in vitro selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Isolation of protein ligands from large peptoid libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Identification of a peptoid inhibitor of the proteasome 19S regulatory particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

The biology of VEGF and its receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Large-scale manufacture of peptide therapeutics by chemical synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

HeLa Cell Entry by Guanidinium-Rich β-Peptides: Importance of Specific Cation–Cell Surface Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Selective Binding of TAR RNA by a Tat-Derived β-Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

Residue-based control of helix shape in β-peptide oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.632002

10.1517/17460441.2011.632002

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference