(Q37369326)

20 August 2017

In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX (English)

1 reference

20 August 2017

1 reference

4

William L Jorgensen

1 reference

20 August 2017

5

Alanna Schepartz

1 reference

20 August 2017

3

Julian Tirado-Rives

1 reference

20 August 2017

Julien Michel

1

1 reference

20 August 2017

Elizabeth A Harker

series ordinal

2

1 reference

20 August 2017

language of work or name

English

0 references

publication date

1 May 2009

1 reference

Journal of the American Chemical Society

20 August 2017

1 reference

20 August 2017

131

1 reference

20 August 2017

18

1 reference

20 August 2017

6356-6357

1 reference

Efficient drug lead discovery and optimization

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Cell-permeable beta-peptide inhibitors of p53/hDM2 complexation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Beta-peptides with improved affinity for hDM2 and hDMX.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Computations of standard binding free energies with molecular dynamics simulations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Targeting the MDM2-p53 interaction for cancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Molecular basis for the inhibition of p53 by Mdmx

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Hdmx modulates the outcome of p53 activation in human tumor cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

A rapid library screen for tailoring beta-peptide structure and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Molecular modeling of organic and biomolecular systems using BOSS and MCPRO.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Solution structure of a beta-peptide ligand for hDM2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

The many roles of computation in drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

VMD: visual molecular dynamics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

ADME investigations of unnatural peptides: distribution of a 14C-labeled beta 3-octaarginine in rats

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

Helical beta-peptide inhibitors of the p53-hDM2 interaction.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754742

The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidases

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19415930

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19415930

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19415930

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JA901478E

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19415930

1 reference