(Q28257444)

1

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Ee Tsin Wong

2

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Mengjia Tang

3

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Jayne M Stommel

4

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Geoffrey M Wahl

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

3 November 2006

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published in

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volume

281

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issue

44

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page(s)

33036-44

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cites work

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21 January 2018

Surfing the p53 network

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The p53 tumor suppressor gene and nuclear protein: basic science review and relevance in the management of bladder cancer

21 January 2018

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A review of p53 expression and mutation in human benign, low malignant potential, and invasive epithelial ovarian tumors

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Regulation of p53 stability by Mdm2

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

21 January 2018

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

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Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

21 January 2018

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ATM signaling and genomic stability in response to DNA damage

21 January 2018

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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

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Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

21 January 2018

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

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Chemotherapy-induced secondary malignancies

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

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Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

21 January 2018

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Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

21 January 2018

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An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

21 January 2018

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MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

21 January 2018

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

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Mdmx as an essential regulator of p53 activity

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DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

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MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

21 January 2018

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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Small molecule antagonists of the MDM2 oncoprotein as anticancer agents

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ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

21 January 2018

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

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Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo

21 January 2018

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

21 January 2018

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Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells

21 January 2018

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

21 January 2018

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

21 January 2018

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Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

21 January 2018

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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

21 January 2018

1 reference

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14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605405200

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M605405200

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M605405200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16905769

1 reference

Consolidated OpenCitations Corpus – April 2017