(Q22010970)

GOA release 2020-03-11

MDM2 proto-oncogene

1 reference

protein-containing complex assembly

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

D A Sharp

1

D A

Sharp

1 reference

7 February 2023

S A Kratowicz

series ordinal

2

author given names

S A

author last names

Kratowicz

1 reference

7 February 2023

M J Sank

series ordinal

3

author given names

M J

author last names

Sank

1 reference

7 February 2023

D L George

series ordinal

4

author given names

D L

author last names

George

1 reference

Journal of Biological Chemistry

7 February 2023

language of work or name

English

0 references

publication date

31 December 1999

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published in

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volume

274

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issue

53

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page(s)

38189-96

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cites work

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

The MDM2 gene amplification database

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Mdm2: keeping p53 under control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

The RING finger domain: a recent example of a sequence-structure family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Does this have a familiar RING?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Complex formation by the Drosophila MSL proteins: role of the MSL2 RING finger in protein complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

mdm2 expression is induced by wild type p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

7 January 2021

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

7 January 2021

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

7 January 2021

Metal and RNA binding properties of the hdm2 RING finger domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.53.38189

7 January 2021