(Q40244145)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

title

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Baoli Hu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Daniele M Gilkes

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Said M Sebti

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Jiandong Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

language of work or name

English

0 references

publication date

11 August 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

28 December 2019

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

33030-33035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

issue

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

MDM2 is a central node in the p53 pathway: 12 years and counting

28 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Mdmx as an essential regulator of p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Regulation of p53-MDMX interaction by casein kinase 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C600147200

21 January 2018

Identifiers

DOI

10.1074/JBC.C600147200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16905541%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference