(Q44521310)

3 December 2017

title

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. (English)

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3 December 2017

Petra de Graaf

1

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3 December 2017

Natalie A Little

2

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3 December 2017

Yolande F M Ramos

3

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3 December 2017

Erik Meulmeester

4

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3 December 2017

Stef J F Letteboer

5

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3 December 2017

Aart G Jochemsen

6

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3 December 2017

language of work or name

English

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publication date

21 July 2003

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Journal of Biological Chemistry

3 December 2017

published in

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3 December 2017

volume

278

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3 December 2017

issue

40

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3 December 2017

page(s)

38315-38324

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p53: oncogene or anti-oncogene?

3 December 2017

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Regulation of p53 stability by Mdm2

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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MdmX protects p53 from Mdm2-mediated degradation

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

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MDM2 interacts with MDMX through their RING finger domains

21 January 2018

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

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MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

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Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target

21 January 2018

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Constitutive mdmx expression during cell growth, differentiation, and DNA damage

21 January 2018

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MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

21 January 2018

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Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

21 January 2018

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DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms

21 January 2018

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21 January 2018

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21 January 2018

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

21 January 2018

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

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Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

21 January 2018

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A functional p53-responsive intronic promoter is contained within the humanmdm2gene

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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Critical role for a central part of Mdm2 in the ubiquitylation of p53.

21 January 2018

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A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

21 January 2018

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Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.

21 January 2018

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Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation

21 January 2018

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Critical contribution of the MDM2 acidic domain to p53 ubiquitination

21 January 2018

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Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213034200

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213034200

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213034200

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213034200

21 January 2018

Identifiers

DOI

10.1074/JBC.M213034200

1 reference

3 December 2017

1 reference