(Q38015814)

27 August 2017

title

Liver autophagy: physiology and pathology (English)

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27 August 2017

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Masaaki Komatsu

1

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publication date

1 June 2012

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27 August 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

Journal of Biochemistry

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27 August 2017

volume

152

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27 August 2017

issue

1

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27 August 2017

page(s)

5-15

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Autophagy fights disease through cellular self-digestion

27 August 2017

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RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

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21 January 2018

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21 January 2018

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21 January 2018

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Excess peroxisomes are degraded by autophagic machinery in mammals

21 January 2018

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Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

21 January 2018

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An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

21 January 2018

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Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.

21 January 2018

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The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

21 January 2018

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Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

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Structural basis for sorting mechanism of p62 in selective autophagy

21 January 2018

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21 January 2018

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21 January 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Signal integration and diversification through the p62 scaffold protein

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Autophagy: renovation of cells and tissues

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

Induction of autophagy by amino-acid deprivation in perfused rat liver

21 January 2018

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https://api.crossref.org/works/10.1093%2FJB%2FMVS059

21 January 2018

Identifiers

DOI

10.1093/JB/MVS059

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27 August 2017

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