(Q38023321)

27 August 2017

ZEB/miR-200 feedback loop: at the crossroads of signal transduction in cancer (English)

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27 August 2017

Louise Hill

1

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27 August 2017

Gareth Browne

series ordinal

2

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27 August 2017

Eugene Tulchinsky

series ordinal

3

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27 August 2017

language of work or name

English

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publication date

21 July 2012

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International Journal of Cancer

27 August 2017

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27 August 2017

132

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27 August 2017

745-754

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27 August 2017

4

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

27 August 2017

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

21 January 2018

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Epithelial-mesenchymal transitions in development and disease

21 January 2018

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Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer.

21 January 2018

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Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

21 January 2018

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Snail blocks the cell cycle and confers resistance to cell death

21 January 2018

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Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.

21 January 2018

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Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition

21 January 2018

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ZEB proteins link cell motility with cell cycle control and cell survival in cancer.

21 January 2018

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

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Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

21 January 2018

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Cancer stemness and metastasis: therapeutic consequences and perspectives

21 January 2018

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SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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Generation of breast cancer stem cells through epithelial-mesenchymal transition

21 January 2018

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TWISTing an embryonic transcription factor into an oncoprotein

21 January 2018

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Systemic spread is an early step in breast cancer

21 January 2018

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Parallel progression of primary tumours and metastases

21 January 2018

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?Mowat-Wilson? syndrome with and without Hirschsprung disease is a distinct, recognizable multiple congenital anomalies-mental retardation syndrome caused by mutations in the zinc finger homeo box 1B gene

21 January 2018

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Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells

21 January 2018

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The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?

21 January 2018

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The role of the ZEB family of transcription factors in development and disease.

21 January 2018

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

21 January 2018

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Potential mRNA degradation targets of hsa-miR-200c, identified using informatics and qRT-PCR.

21 January 2018

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miR-200b mediates post-transcriptional repression of ZFHX1B.

21 January 2018

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Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin

21 January 2018

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

21 January 2018

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The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

21 January 2018

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A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

21 January 2018

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A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

21 January 2018

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Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

21 January 2018

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MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

21 January 2018

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Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels

21 January 2018

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Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

21 January 2018

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Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer

21 January 2018

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MicroRNAs as regulators of epithelial-mesenchymal transition.

21 January 2018

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MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

21 January 2018

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p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.

21 January 2018

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Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins

21 January 2018

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deltaEF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis.

21 January 2018

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A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

21 January 2018

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Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta

21 January 2018

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An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

21 January 2018

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14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition

21 January 2018

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Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas.

21 January 2018

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Inducible expression of TGFβ, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model

21 January 2018

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Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells

21 January 2018

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An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition

21 January 2018

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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype

21 January 2018

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CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

21 January 2018

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TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

21 January 2018

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TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

21 January 2018

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The epithelial cell default-phenotype hypothesis and its implications for cancer

21 January 2018

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Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors

21 January 2018

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Prospective identification of tumorigenic breast cancer cells

21 January 2018

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

21 January 2018

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Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

21 January 2018

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

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EMT and dissemination precede pancreatic tumor formation

21 January 2018

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The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.

21 January 2018

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SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.

21 January 2018

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Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells

21 January 2018

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Rational targeting of Notch signaling in cancer

21 January 2018

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Cancer stem cells and the ontogeny of lung cancer

21 January 2018

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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

21 January 2018

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Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

21 January 2018

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Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

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The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

21 January 2018

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Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells

21 January 2018

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The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice

21 January 2018

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Wnt/beta-catenin signaling in cancer stemness and malignant behavior

21 January 2018

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A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer

21 January 2018

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β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.

21 January 2018

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Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro

21 January 2018

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Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation

21 January 2018

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Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

21 January 2018

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CCN5, a novel transcriptional repressor of the transforming growth factor β signaling pathway

21 January 2018

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Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.

21 January 2018

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CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer

21 January 2018

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

21 January 2018

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Ras alters epithelial-mesenchymal transition in response to TGFbeta by reducing actin fibers and cell-matrix adhesion

21 January 2018

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Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.

21 January 2018

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Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

21 January 2018

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ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

21 January 2018

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TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer

21 January 2018

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Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

21 January 2018

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

21 January 2018

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In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

21 January 2018

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Zeb1 links epithelial-mesenchymal transition and cellular senescence

21 January 2018

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

21 January 2018

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The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.

21 January 2018

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Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

21 January 2018

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Multiple tumor suppressor pathways negatively regulate telomerase

21 January 2018

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Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells.

21 January 2018

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New plays in the p53 theater

21 January 2018

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The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation

21 January 2018

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deltaEF1 repressor controls selectively p53 family members during differentiation.

21 January 2018

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ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia

21 January 2018

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p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.

21 January 2018

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An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

21 January 2018

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miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27708

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27 August 2017

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