(Q38025389)

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Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models

scientific article published on 06 July 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models (English)

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

pathophysiology

1 reference

based on heuristic

inferred from title

author name string

Christopher L-H Huang

1

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Lily Lei

2

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Gareth D K Matthews

3

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Yanmin Zhang

4

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Ming Lei

5

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

publication date

6 July 2012

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Frontiers in Physiology

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

234

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

SCN5A channelopathies--an update on mutations and mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Genetic Na+ channelopathies and sinus node dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

SCN5A and sinoatrial node pacemaker function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Evolution of voltage-gated Na(+) channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

A sodium-channel mutation causes isolated cardiac conduction disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Resurgence of sodium channel research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Cardiac conduction defects associate with mutations in SCN5A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

6 September 2017

Cardiac ion channel gene mutations in sudden infant death syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

14 September 2017

Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

14 September 2017

Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

23 June 2018

The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

23 June 2018

TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

31 August 2018

Contribution of neuronal sodium channels to the cardiac fast sodium current INa is greater in dog heart Purkinje fibers than in ventricles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

31 August 2018

Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

31 August 2018

Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390692

31 August 2018

Structure and function of the simian sinoatrial node (Macaca fascicularis)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiology of the ageing rabbit and cat sinoatrial node--a comparative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sinus node function: normal and pathological

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Brugada syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent sinus nodal electrograms during abnormally prolonged postpacing atrial pauses in sick sinus syndrome in humans: sinoatrial block vs overdrive suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22783200

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FPHYS.2012.00234

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

ResearchGate publication ID

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