(Q38027770)

27 August 2017

title

HIV-1 reservoirs in breast milk and challenges to elimination of breast-feeding transmission of HIV-1. (English)

1 reference

27 August 2017

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Philippe Van de Perre

1

Philippe Van de Perre

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Pierre-Alain Rubbo

2

Pierre-Alain Rubbo

1 reference

27 August 2017

5

Thorkild Tylleskär

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Edouard Tuaillon

8

Edouard Tuaillon

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Nicolas Nagot

4

Nicolas Nagot

1 reference

27 August 2017

6

Philippe Lepage

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27 August 2017

7

Jean-Pierre Vendrell

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27 August 2017

Johannes Viljoen

3

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27 August 2017

language of work or name

English

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publication date

1 July 2012

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Science Translational Medicine

27 August 2017

published in

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27 August 2017

volume

4

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27 August 2017

issue

143

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27 August 2017

page(s)

143sr3

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The mucosal immune system and its integration with the mammary glands

27 August 2017

cites work

1 reference

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The Immune System of Breast Milk: Antimicrobial and Anti-inflammatory Properties

21 January 2018

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Cumulative exposure to cell-free HIV in breast milk, rather than feeding pattern per se, identifies postnatally infected infants

21 January 2018

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Human immunodeficiency virus antibodies of IgG, IgA, and IgM subclasses in milk of seropositive mothers

21 January 2018

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21 January 2018

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Mother to child transmission of HIV among Zimbabwean women who seroconverted postnatally: prospective cohort study

21 January 2018

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Influence of infant-feeding patterns on early mother-to-child transmission of HIV-1 in Durban, South Africa: a prospective cohort study. South African Vitamin A Study Group

21 January 2018

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Early exclusive breastfeeding reduces the risk of postnatal HIV-1 transmission and increases HIV-free survival

21 January 2018

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Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1.

21 January 2018

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Associations between breast milk viral load, mastitis, exclusive breast-feeding, and postnatal transmission of HIV.

21 January 2018

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Microbial translocation is a cause of systemic immune activation in chronic HIV infection

21 January 2018

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Antiretroviral regimens in pregnancy and breast-feeding in Botswana

21 January 2018

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Triple antiretroviral compared with zidovudine and single-dose nevirapine prophylaxis during pregnancy and breastfeeding for prevention of mother-to-child transmission of HIV-1 (Kesho Bora study): a randomised controlled trial

21 January 2018

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Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal mother-to-child transmission in Rwanda

21 January 2018

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Maternal or infant antiretroviral drugs to reduce HIV-1 transmission

21 January 2018

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Triple-antiretroviral prophylaxis to prevent mother-to-child HIV transmission through breastfeeding--the Kisumu Breastfeeding Study, Kenya: a clinical trial

21 January 2018

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Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission

21 January 2018

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Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials

21 January 2018

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Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Characterisation of host defence proteins in milk using a proteomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

The immunological components of human milk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Lactoferrin: an important host defence against microbial and viral attack.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Killing of gram-negative bacteria by lactoferrin and lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Composition, structure and absorption of milk lipids: a source of energy, fat-soluble nutrients and bioactive molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Mice, microbes and models of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Abundant human beta-defensin-1 expression in milk and mammary gland epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Inhibitory effects of human and bovine milk constituents on rotavirus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Role and significance of the complement system in mucosal immunity: particular reference to the human breast milk complement

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Necrotising enterocolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Breast milk as the gold standard for protective nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Association between breast milk erythropoietin and reduced risk of mother-to-child transmission of HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Isolation and characterization of HIV-1-infected resting CD4+ T lymphocytes in breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Identification of nestin-positive putative mammary stem cells in human breastmilk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Unravelling the mystery of stem/progenitor cells in human breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Breast milk CD4+ T cells express high levels of C chemokine receptor 5 and CXC chemokine receptor 4 and are preserved in HIV-infected mothers receiving highly active antiretroviral therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human breast milk T lymphocytes display the phenotype and functional characteristics of memory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human milk-derived B cells: a highly activated switched memory cell population primed to secrete antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human immunodeficiency virus-specific CD8(+) T cells in human breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Prevalence and magnitude of human immunodeficiency virus (HIV) type 1-specific lymphocyte responses in breast milk from HIV-1-seropositive women

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Effect of breast milk of healthy and allergic mothers on in vitro stimulation of cord blood lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Breast milk macrophages spontaneously produce granulocyte-macrophage colony-stimulating factor and differentiate into dendritic cells in the presence of exogenous interleukin-4 alone

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV infection and the gastrointestinal immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

The potential impact of CD4+ T cell activation and enhanced Th1/Th2 cytokine ratio on HIV-1 secretion in the lungs of individuals with advanced AIDS and active pulmonary infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Low and undetectable breast milk interleukin-7 concentrations are associated with reduced risk of postnatal HIV transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Risk factors for subclinical mastitis among HIV-infected and uninfected women in Lusaka, Zambia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Subclinical mastitis, cell-associated HIV-1 shedding in breast milk, and breast-feeding transmission of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Primary human mammary epithelial cells endocytose HIV-1 and facilitate viral infection of CD4+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Detection of a large T-cell reservoir able to replicate HIV-1 actively in breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Diversity of HIV-1 RNA and DNA in breast milk from HIV-1-infected mothers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human milk contains S100B protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Compartmentalization of HIV-1 between Breast Milk and Blood of HIV-Infected Mothers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Effect of perinatal zidovudine prophylaxis on the evolution of cell-free HIV-1 RNA in breast milk and on postnatal transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Inhibition of DC-SIGN-mediated transmission of human immunodeficiency virus type 1 by Toll-like receptor 3 signalling in breast milk macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I transmission via breastfeeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Cell-free virus in breast milk of HIV-1-seropositive women

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Cell-free human immunodeficiency virus type 1 in breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human Immunodeficiency Virus Type 1 RNA in Breast‐Milk Components

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Quantitation of HIV-1 RNA in breast milk by real time PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Subclinical mastitis as a risk factor for mother-infant HIV transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Infective and anti-infective properties of breastmilk from HIV-1-infected women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Transmission of cell-free and cell-associated HIV-1 through breast-feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Milk-borne transmission of human T-cell leukemia virus type I in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Immunologic aspects of human colostrum and milk. I. Distribution characteristics and concentrations of immunoglobulins at different times after the onset of lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Innate factors in human breast milk inhibit cell-free HIV-1 but not cell-associated HIV-1 infection of CD4+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Initiation of antiretroviral treatment in women after delivery can induce multiclass drug resistance in breastfeeding HIV-infected infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Studies on antiretroviral drug concentrations in breast milk: validation of a liquid chromatography-tandem mass spectrometric method for the determination of 7 anti-human immunodeficiency virus medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Prevention of mother-to-child transmission of HIV-1 through breast-feeding by treating infants prophylactically with lamivudine in Dar es Salaam, Tanzania: the Mitra Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Strategies to prevent mother-to-child transmission of HIV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Early Antiretroviral Therapy and Mortality among HIV-Infected Infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age: 24 week results

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

Universal antiretroviral therapy for pregnant and breast-feeding HIV-1-infected women: towards the elimination of mother-to-child transmission of HIV-1 in resource-limited settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003327

10.1126/SCITRANSLMED.3003327

21 January 2018

Identifiers

DOI

1 reference

release_4lxqa4muqraalo7t3zthcdhefu

27 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4lxqa4muqraalo7t3zthcdhefu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference