(Q38038868)

27 August 2017

title

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO. (English)

1 reference

single-nucleotide polymorphism

27 August 2017

0 references

1 reference

2

H B Schiöth

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27 August 2017

J A Jacobsson

1

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27 August 2017

R Fredriksson

series ordinal

3

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27 August 2017

language of work or name

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29 August 2012

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27 August 2017

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27 August 2017

volume

13

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27 August 2017

issue

12

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27 August 2017

page(s)

1096-1109

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

27 August 2017

cites work

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From GWAS to biology: lessons from FTO.

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Where to go with FTO?

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The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily

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Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

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N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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An obesity-associated FTO gene variant and increased energy intake in children

21 January 2018

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Variation in the FTO gene influences food intake but not energy expenditure

21 January 2018

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Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

21 January 2018

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The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

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Obesity-associated cognitive decline: excess weight affects more than the waistline

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Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

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Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study

21 January 2018

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The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

21 January 2018

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Regulation of FTO and FTM expression during human preadipocyte differentiation.

21 January 2018

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Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans

21 January 2018

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The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients.

21 January 2018

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Subcutaneous and visceral adipose tissue FTO gene expression and adiposity, insulin action, glucose metabolism, and inflammatory adipokines in type 2 diabetes mellitus and in health.

21 January 2018

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Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Regulation of Fto/Ftm gene expression in mice and humans

21 January 2018

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Inactivation of the Fto gene protects from obesity

21 January 2018

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

21 January 2018

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Overexpression of Fto leads to increased food intake and results in obesity

21 January 2018

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21 January 2018

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28-way vertebrate alignment and conservation track in the UCSC Genome Browser

21 January 2018

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21 January 2018

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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice

21 January 2018

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Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

21 January 2018

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A map of human genome variation from population-scale sequencing

21 January 2018

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Histone deacetylase 9 is a negative regulator of adipogenic differentiation

21 January 2018

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Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP

21 January 2018

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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

21 January 2018

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Alms1-disrupted mice recapitulate human Alström syndrome

21 January 2018

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Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes

21 January 2018

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Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling

21 January 2018

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The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

21 January 2018

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Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

21 January 2018

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The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study

21 January 2018

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Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus

21 January 2018

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Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1

21 January 2018

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Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly

21 January 2018

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The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924.

21 January 2018

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Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test

21 January 2018

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Life course variations in the associations between FTO and MC4R gene variants and body size

21 January 2018

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FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity

21 January 2018

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Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women

21 January 2018

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Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population

21 January 2018

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FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness

21 January 2018

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Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans

21 January 2018

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Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France.

21 January 2018

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Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

21 January 2018

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Association of the FTO gene with BMI.

21 January 2018

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21 January 2018

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Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain.

21 January 2018

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Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study

21 January 2018

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Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study

21 January 2018

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Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany

21 January 2018

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21 January 2018

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21 January 2018

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Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty

21 January 2018

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Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population.

21 January 2018

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Recapitulation of genome-wide association studies on body mass index in the Korean population

21 January 2018

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Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

21 January 2018

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FTO variants are associated with obesity in the Chinese and Malay populations in Singapore

21 January 2018

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Variations in the FTO gene are associated with severe obesity in the Japanese

21 January 2018

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Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population

21 January 2018

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Replication of genetic effects of FTO polymorphisms on BMI in a Korean population

21 January 2018

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Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children

21 January 2018

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Association of morbid obesity with FTO and INSIG2 allelic variants

21 January 2018

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A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population

21 January 2018

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The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China

21 January 2018

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Association between the FTO gene and overweight in Japanese children and adolescents

21 January 2018

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Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population

21 January 2018

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Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

21 January 2018

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Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

21 January 2018

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Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.

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Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction.

21 January 2018

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The rs7204609 polymorphism in the fat mass and obesity-associated gene is positively associated with central obesity and microalbuminuria in patients with type 2 diabetes from Southern Brazil.

21 January 2018

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21 January 2018

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FTO gene variation and measures of body mass in an African population

21 January 2018

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FTO genetic variation and association with obesity in West Africans and African Americans

21 January 2018

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FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women

21 January 2018

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Genome-wide association of anthropometric traits in African- and African-derived populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Genome-wide association of BMI in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Fine mapping of the association with obesity at the FTO locus in African-derived populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Gene-diet interactions in childhood obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Gene-environment interactions and obesity--further aspects of genomewide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Gene-environment interactions in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Physical activity and the association of common FTO gene variants with body mass index and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Genetic determinants of common obesity and their value in prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Associations of Variants inFTOand NearMC4RWith Obesity Traits in South Asian Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Common variants of FTO and the risk of obesity and type 2 diabetes in Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

TheFTOGene Is Associated With Adulthood Obesity in the Mexican Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Anti-inflammatory Profile of FTO Gene Expression in Adipose Tissues From Morbidly Obese Women

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Meta-analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

The FTO Gene, Implicated in Human Obesity, Is Found Only in Vertebrates and Marine Algae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Variants in the FTO gene are associated with common obesity in the Belgian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

Physical activity attenuates the body mass index–increasing influence of genetic variation in the FTO gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1467-789X.2012.01025.X

10.1111/J.1467-789X.2012.01025.X

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference