(Q38040668)

27 August 2017

title

Biosynthesis of clavam metabolites (English)

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27 August 2017

Susan E Jensen

1

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27 August 2017

publication date

5 September 2012

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Journal of Industrial Microbiology & Biotechnology

27 August 2017

published in

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27 August 2017

volume

39

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27 August 2017

issue

10

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27 August 2017

page(s)

1407-1419

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Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis

27 August 2017

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ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid

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Chemistry and biosynthesis of clavulanic acid and other clavams

21 January 2018

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Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation.

21 January 2018

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Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.

21 January 2018

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Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway

21 January 2018

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Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine

21 January 2018

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The beta-lactam antibiotics: past, present, and future

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Industrial production of beta-lactam antibiotics

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X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

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Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase

21 January 2018

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A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus

21 January 2018

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Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization

21 January 2018

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Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

21 January 2018

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Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene

21 January 2018

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Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus

21 January 2018

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Biosynthesis and molecular genetics of clavulanic acid

21 January 2018

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ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

21 January 2018

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Cloning and characterization of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces clavuligerus

21 January 2018

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5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus

21 January 2018

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Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

21 January 2018

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Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.

21 January 2018

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A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development

21 January 2018

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Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant

21 January 2018

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Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor

21 January 2018

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Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid

21 January 2018

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Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid

21 January 2018

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Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus

21 January 2018

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The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways

21 January 2018

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The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene

21 January 2018

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Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine

21 January 2018

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DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences

21 January 2018

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A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus

21 January 2018

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Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus

21 January 2018

1 reference

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Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family

21 January 2018

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A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Elucidation of the order of oxidations and identification of an intermediate in the multistep clavaminate synthase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Alanylclavam biosynthetic genes are clustered together with one group of clavulanic acid biosynthetic genes in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Origin of the β-Lactam Carbons in Clavulanic Acid from an Unusual Thiamine Pyrophosphate-Mediated Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-012-1191-0

Biological properties and mode of action of clavams

21 January 2018

1 reference

12 December 2020

Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.

1 reference

12 December 2020

Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus

1 reference

12 December 2020

The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces

1 reference

12 December 2020

Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity

1 reference

12 December 2020

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

1 reference

12 December 2020

Characterization of binding sequences for butyrolactone autoregulator receptors in streptomycetes.

1 reference

12 December 2020

Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus

1 reference

12 December 2020

Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.

1 reference

12 December 2020

Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor

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12 December 2020

Naturally-occurring beta-lactamase inhibitors with antibacterial activity

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12 December 2020

The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini

1 reference

12 December 2020

10.1007/S10295-012-1191-0

Identifiers

DOI

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27 August 2017

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