(Q34463045)

2 August 2017

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid (English)

1 reference

2 August 2017

Christopher J. Schofield

6

1 reference

2 August 2017

Nadia J Kershaw

2

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author name string

Haren Arulanantham

1

1 reference

2 August 2017

Kirsty S Hewitson

3

1 reference

2 August 2017

Claire E Hughes

4

1 reference

2 August 2017

Jan E Thirkettle

5

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2 August 2017

language of work or name

English

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publication date

26 October 2005

1 reference

Journal of Biological Chemistry

2 August 2017

9

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based on heuristic

inferred from page(s)

published in

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2 August 2017

281

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2 August 2017

279-287

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2 August 2017

1

1 reference

Chemistry and biosynthesis of clavulanic acid and other clavams

2 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

New reactions in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Origin of the β-Lactam Carbons in Clavulanic Acid from an Unusual Thiamine Pyrophosphate-Mediated Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

beta-Lactam synthetase: a new biosynthetic enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

T-Coffee: A novel method for fast and accurate multiple sequence alignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Movement of the biotin carboxylase B-domain as a result of ATP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

The case for open-source software in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

[48] Phosphoenolpyruvate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

X-ray crystal structure of glycinamide ribonucleotide synthetase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

ATPase activity of biotin carboxylase provides evidence for initial activation of HCO3- by ATP in the carboxylation of biotin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

A functional analysis of the allosteric nucleotide monophosphate binding site of carbamoyl phosphate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

D-Ala-D-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507711200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507711200

1 reference

2 August 2017

1 reference