(Q38042870)

27 August 2017

title

Endothelial dysfunction and hypertension in aging (English)

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27 August 2017

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arterial hypertension

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1

Yukihito Higashi

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27 August 2017

2

Yasuki Kihara

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27 August 2017

3

Kensuke Noma

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27 August 2017

publication date

13 September 2012

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27 August 2017

published in

Hypertension Research

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27 August 2017

volume

35

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27 August 2017

issue

11

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27 August 2017

page(s)

1039-1047

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https://scigraph.springernature.com/pub.10.1038/hr.2012.138

27 August 2017

exact match

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Hypertension, angiotensin II, and oxidative stress

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Endothelial function and oxidative stress in cardiovascular diseases

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Regulatory functions of the vascular endothelium

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Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress

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Prognostic significance of endothelial dysfunction in hypertensive patients

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Endothelial function: cardiac events

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Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction

21 January 2018

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Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

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Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

21 January 2018

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Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases

21 January 2018

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Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans

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Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function

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Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study

21 January 2018

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Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.

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Role of nitric oxide in the regulation of digital pulse volume amplitude in humans

21 January 2018

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Digital assessment of endothelial function and ischemic heart disease in women

21 January 2018

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Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension

21 January 2018

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Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats

21 January 2018

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Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

21 January 2018

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New tetrahydrobiopterin-dependent systems

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Circulating endothelial progenitor cells and cardiovascular outcomes

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Stem cells and the regeneration of the aging cardiovascular system

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Nitric oxide and endothelial cellular senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

The telomerase tale in vascular aging: regulation by estrogens and nitric oxide signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Endothelial dysfunction in human disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Nitric oxide in hypertension

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Influence of diabetes mellitus on heart failure risk and outcome

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Homocysteine and endothelial function in human studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-associated kinase activity, endothelial function, and cardiovascular risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-kinase is an important therapeutic target in cardiovascular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Involvement of Rho GTPases in the transcriptional inhibition of preproendothelin-1 gene expression by simvastatin in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Physiological role of ROCKs in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Rho-kinase: important new therapeutic target in cardiovascular diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Telomeres and human disease: ageing, cancer and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Protein composition of catalytically active human telomerase from immortal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

Telomere length and replicative aging in human vascular tissues

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Telomere dysfunction in hypertension

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Healthy aging and disease: role for telomere biology?

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell

21 January 2018

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eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

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Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Telomeres and cardiovascular disease: does size matter?

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Different telomere damage signaling pathways in human and mouse cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Vascular cell senescence: contribution to atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Acute Simultaneous Stimulation of Nitric Oxide and Oxygen Radicals by Angiotensin II in Humans in Vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

Age and the Cardiovascular System

21 January 2018

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Physiology of cardiovascular aging

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Alterations in the vasoreactivity of hypertensive rat aortic rings: role of nitric oxide and superoxide radicals

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7 January 2021

Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Positive association of pro-inflammatory biomarkers and increased oxidative stress in the healthy elderly

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

The Interstitium of the Human Arterial Wall Contains Very Large Amounts of Extracellular Superoxide Dismutase

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Atherogenic concentrations of native low-density lipoproteins down-regulate nitric-oxide-synthase mRNA and protein levels in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress

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https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Nitric oxide activates telomerase and delays endothelial cell senescence

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Telomere attrition in white blood cell correlating with cardiovascular damage

1 reference

https://api.crossref.org/works/10.1038%2FHR.2012.138

7 January 2021

Identifiers

DOI

10.1038/HR.2012.138

1 reference

27 August 2017

1 reference