(Q38043935)

27 August 2017

title

12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance (English)

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27 August 2017

Stefan Uderhardt

1

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27 August 2017

Gerhard Krönke

series ordinal

2

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27 August 2017

language of work or name

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15 September 2012

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Journal of Molecular Medicine

27 August 2017

published in

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27 August 2017

volume

90

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27 August 2017

issue

11

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27 August 2017

page(s)

1247-1256

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Inflammation and immune regulation by 12/15-lipoxygenases

27 August 2017

cites work

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12 December 2020

Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40

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12 December 2020

Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease

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12 December 2020

Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production

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12 December 2020

Resolution of inflammation: the beginning programs the end

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12 December 2020

Emerging roles of PPARs in inflammation and immunity

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12 December 2020

Anti-inflammatory properties of lipid oxidation products

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12 December 2020

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

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12 December 2020

Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase.

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12 December 2020

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

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12 December 2020

Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure

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12 December 2020

Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma

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12 December 2020

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes

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12 December 2020

The role of defective clearance of apoptotic cells in systemic autoimmunity.

1 reference

12 December 2020

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet

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12 December 2020

Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice

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12 December 2020

15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma

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12 December 2020

Arachidonate 15-lipoxygenase: immunocytochemical localization in blood and airway cells

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12 December 2020

12/15-lipoxygenase, oxidative modification of LDL and atherogenesis

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12 December 2020

Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling

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12 December 2020

12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo

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12 December 2020

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

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12 December 2020

Esterified eicosanoids: generation, characterization and function

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12 December 2020

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

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12 December 2020

Lipid mediator class switching during acute inflammation: signals in resolution.

1 reference

12 December 2020

Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6

1 reference

12 December 2020

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

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12 December 2020

Protective role of phospholipid oxidation products in endotoxin-induced tissue damage

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12 December 2020

12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB.

1 reference

12 December 2020

Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease

1 reference

12 December 2020

Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis

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12 December 2020

Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.

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12 December 2020

12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo

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12 December 2020

Lipoxin syntheses by arachidonate 12- and 5-lipoxygenases purified from porcine leukocytes

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12 December 2020

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12 December 2020

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

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12 December 2020

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

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12 December 2020

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

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12 December 2020

Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

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12 December 2020

Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.

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12 December 2020

Oxidized phospholipid signaling in immune cells

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12 December 2020

The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo

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12 December 2020

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

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12 December 2020

Role of specific isoforms of protein kinase C in angiotensin II and lipoxygenase action in rat adrenal glomerulosa cells

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12 December 2020

Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects

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12 December 2020

Generation and biological activities of oxidized phospholipids

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12 December 2020

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

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12 December 2020

Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes

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12 December 2020

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

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12 December 2020

Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells

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12 December 2020

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase

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12 December 2020

12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice

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12 December 2020

15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist

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12 December 2020

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells

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12 December 2020

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice

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12 December 2020

Signaling mechanisms of nuclear factor-kappab-mediated activation of inflammatory genes by 13-hydroperoxyoctadecadienoic acid in cultured vascular smooth muscle cells

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12 December 2020

Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake

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12 December 2020

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation

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12 December 2020

Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation

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12 December 2020

Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein

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12 December 2020

Functional and pathological roles of the 12- and 15-lipoxygenases

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12 December 2020

Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine

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12 December 2020

Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids.

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12 December 2020

Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice

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12 December 2020

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

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12 December 2020

Transcriptomic analyses of murine resolution-phase macrophages

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12 December 2020

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators

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12 December 2020

Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms

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12 December 2020

Regulation of bone mass in mice by the lipoxygenase gene Alox15

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12 December 2020

Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase

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12 December 2020

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

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12 December 2020

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

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12 December 2020

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis

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12 December 2020

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

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12 December 2020

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

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12 December 2020

IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression

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12 December 2020

12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kappaB.

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12 December 2020

PPARs and the complex journey to obesity

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12 December 2020

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

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12 December 2020

Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma

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12 December 2020

12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells

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12 December 2020

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12 December 2020

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

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12 December 2020

Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis

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12 December 2020

IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats

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12 December 2020

The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth

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12 December 2020

Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia

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12 December 2020

Phagocyte partnership during the onset and resolution of inflammation.

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12 December 2020

Old and new generation lipid mediators in acute inflammation and resolution

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12 December 2020

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction

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12 December 2020

Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein.

1 reference

12 December 2020

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

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12 December 2020

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

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12 December 2020

Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids

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12 December 2020

Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

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12 December 2020

Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein

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12 December 2020

Increased Production of 12/15 Lipoxygenase Eicosanoids Accelerates Monocyte/Endothelial Interactions in Diabetic db/db Mice

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12 December 2020

The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angioten

1 reference

12 December 2020

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

1 reference

12 December 2020

Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase

1 reference

12 December 2020

Peroxisome proliferator-activated receptor γ activators inhibit interleukin-12 production in murine dendritic cells

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12 December 2020

Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands

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12 December 2020

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

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12 December 2020

Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13.

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12 December 2020

Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation

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12 December 2020

The diversity of the lipoxygenase family. Many sequence data but little information on biological significance

1 reference

12 December 2020

Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids

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12 December 2020

IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication

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12 December 2020

Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.

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12 December 2020

IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor

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12 December 2020

Lipoxygenase genes and their targeted disruption

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12 December 2020

Development of myeloproliferative disease in 12/15-lipoxygenase deficiency

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12 December 2020

Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes

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12 December 2020

The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants

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12 December 2020

Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

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12 December 2020

A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense

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12 December 2020

10.1007/S00109-012-0954-4

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

1001244396

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