(Q38044445)

27 August 2017

title

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling (English)

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27 August 2017

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ChEBI release 2020-05-28

3

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27 August 2017

4

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27 August 2017

Patricia Gómez-Suaga

1

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27 August 2017

Grant C Churchill

series ordinal

2

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27 August 2017

publication date

1 October 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

5

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27 August 2017

page(s)

1140-1146

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

27 August 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

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Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

21 January 2018

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

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LRRK2 signaling pathways: the key to unlocking neurodegeneration?

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

21 January 2018

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

21 January 2018

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A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

21 January 2018

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

21 January 2018

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Protein misfolding disorders and macroautophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Autophagy gone awry in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120138

Eaten alive: a history of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Endosome-lysosome fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 and human disease: a complicated question or a question of complexes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Membrane trafficking events that partake in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Endocytosis and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Termination of autophagy and reformation of lysosomes regulated by mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Regulation of physiologic actions of LRRK2: focus on autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Calcium signalling remodelling and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

NAADP: a universal Ca2+ trigger

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

NAADP mobilizes calcium from acidic organelles through two-pore channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

NAADP induces pH changes in the lumen of acidic Ca2+ stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Identification of a chemical probe for NAADP by virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120138

21 January 2018

Identifiers

DOI

10.1042/BST20120138

1 reference

27 August 2017

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