(Q38045180)

English

From mice to humans

scientific article published on December 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

9 references

13 March 2019

14 March 2019

19 March 2019

24 March 2019

20 June 2019

19 September 2019

11 August 2020

3 December 2020

4 February 2021

From mice to humans (English)

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

7 references

13 March 2019

14 March 2019

19 March 2019

24 March 2019

20 June 2019

19 September 2019

11 August 2020

type 2 diabetes

3 references

19 September 2019

11 August 2020

4 February 2021

biomedical investigative technique

1 reference

19 September 2019

genome-wide association study

1 reference

11 August 2020

animal disease model

1 reference

3 December 2020

2

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

object named as

Fiona McMurray

1

0 references

object named as

Roger D Cox

3

0 references

publication date

1 December 2012

10 references

Europe PubMed Central

PMC publication ID

27 August 2017

13 March 2019

14 March 2019

19 March 2019

24 March 2019

20 June 2019

19 September 2019

11 August 2020

3 December 2020

4 February 2021

Current diabetes report

10 references

Europe PubMed Central

PMC publication ID

27 August 2017

13 March 2019

14 March 2019

19 March 2019

24 March 2019

20 June 2019

19 September 2019

11 August 2020

3 December 2020

4 February 2021

12

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

651-658

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

https://scigraph.springernature.com/pub.10.1007/s11892-012-0323-2

0 references

Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

FLASH assembly of TALENs for high-throughput genome editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

TALE nucleases: tailored genome engineering made easy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genetic engineering of human pluripotent cells using TALE nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Mouse models and type 2 diabetes: translational opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A conditional knockout resource for the genome-wide study of mouse gene function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

High-throughput mouse phenotyping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genomics, type 2 diabetes, and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Overexpression of Fto leads to increased food intake and results in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Targeting DNA double-strand breaks with TAL effector nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A map of open chromatin in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Inactivation of the Fto gene protects from obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

ENU mutagenesis, a way forward to understand gene function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genome-wide association studies provide new insights into type 2 diabetes aetiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Altering the genome by homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

6 September 2017

Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

23 June 2018

Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

23 June 2018

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

23 June 2018

Primer and interviews: promises and realities of induced pluripotent stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

31 August 2018

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

31 August 2018

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3488608

31 August 2018

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0323-2

21 January 2018

Identifiers

10.1007/S11892-012-0323-2

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

27 August 2017

ResearchGate publication ID

0 references

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