(Q38056312)

English

Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets

scientific article published on February 2013

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scholarly article

1 reference

Europe PubMed Central

27 August 2017

Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets (English)

1 reference

Europe PubMed Central

27 August 2017

0 references

1 reference

based on heuristic

inferred from title

circulatory system

1 reference

based on heuristic

inferred from title

author name string

Heike Wulff

1

1 reference

Europe PubMed Central

27 August 2017

Ralf Köhler

2

1 reference

Europe PubMed Central

27 August 2017

language of work or name

0 references

publication date

1 February 2013

1 reference

Europe PubMed Central

27 August 2017

Journal of Cardiovascular Pharmacology

1 reference

Europe PubMed Central

27 August 2017

61

1 reference

Europe PubMed Central

27 August 2017

2

1 reference

Europe PubMed Central

27 August 2017

102-112

1 reference

Europe PubMed Central

27 August 2017

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Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory

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Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells

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Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

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Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels

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Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels

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Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles

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Allosteric block of KCa2 channels by apamin

1 reference

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Calcium-activated potassium channels - a therapeutic target for modulating nitric oxide in cardiovascular disease?

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Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats

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Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

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Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice

1 reference

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Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.

1 reference

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Common variants in KCNN3 are associated with lone atrial fibrillation

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Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

1 reference

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Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.

1 reference

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6 September 2017

In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning

1 reference

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The functional network of ion channels in T lymphocytes

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Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels

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The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy

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Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery

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SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization

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Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure

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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

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Physiology and pathophysiology of potassium channels in gastrointestinal epithelia

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1 reference

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Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2

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International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels

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1 reference

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SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines.

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Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels

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Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

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6 September 2017

An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons

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Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

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6 September 2017

A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes

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6 September 2017

hSK4, a member of a novel subfamily of calcium-activated potassium channels

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6 September 2017

A human intermediate conductance calcium-activated potassium channel

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6 September 2017

Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease

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6 September 2017

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6 September 2017

Preparation and pharmacokinetics of labeled derivatives of apamin

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6 September 2017

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

1 reference

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14 September 2017

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14 September 2017

Functional KCa3.1 K+ channels are required for human lung mast cell migration

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28 September 2017

Localization of the activation gate for small conductance Ca2+-activated K+ channels.

1 reference

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28 September 2017

Developmental regulation of small-conductance Ca2+-activated K+ channel expression and function in rat Purkinje neurons.

1 reference

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28 September 2017

Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

1 reference

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28 September 2017

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

1 reference

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28 September 2017

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1 reference

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23 June 2018

Endothelium-derived hyperpolarizing factor and diabetes

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23 June 2018

Impairment of endothelial SK(Ca) channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats.

1 reference

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23 June 2018

Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis

1 reference

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23 June 2018

Selective blockade of endothelial Ca2+-activated small- and intermediate-conductance K+-channels suppresses EDHF-mediated vasodilation

1 reference

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23 June 2018

Apamin improves reference memory but not procedural memory in rats by blocking small conductance Ca(2+)-activated K(+) channels in an olfactory discrimination task

1 reference

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23 June 2018

K+ channels and the microglial respiratory burst

1 reference

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23 June 2018

Apamin improves learning in an object recognition task in rats.

1 reference

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23 June 2018

Effects of apamin and nicotinic acetylcholine receptor antagonists on inferior collicular seizures.

1 reference

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23 June 2018

Effect of apamin, a toxin that inhibits Ca(2+)-dependent K+ channels, on learning and memory processes.

1 reference

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23 June 2018

Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents.

1 reference

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31 August 2018

CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice

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31 August 2018

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker se

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

SK channels control the firing pattern of midbrain dopaminergic neurons in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthala

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Mechanism of calcium gating in small-conductance calcium-activated potassium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

31 August 2018

Effects on Atrial Fibrillation in Aged Hypertensive Rats by Ca 2+ -Activated K + Channel Inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565027

3 December 2018

Hydrophobic interactions as key determinants to the KCa3.1 channel closed configuration. An analysis of KCa3.1 mutants constitutively active in zero Ca2+

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the Ca²⁺-dependent K⁺ channel, KCNN4/KCa3.1, improves tissue protection and locomotor recovery after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras/MEK/ERK Up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-beta suppression of myogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23107876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/FJC.0B013E318279BA20

1 reference

Europe PubMed Central

27 August 2017

1 reference

Europe PubMed Central

27 August 2017

1 reference

Europe PubMed Central

27 August 2017

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