(Q38058537)

27 August 2017

title

Direct AMP-activated protein kinase activators: a review of evidence from the patent literature (English)

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27 August 2017

Fabrizio Giordanetto

1

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27 August 2017

David Karis

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

8 November 2012

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Expert Opinion on Therapeutic Patents

27 August 2017

published in

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27 August 2017

volume

22

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27 August 2017

issue

12

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27 August 2017

page(s)

1467-1477

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Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits

27 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

21 January 2018

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Synergy in protein engineering. Mutagenic manipulation of protein structure to simplify semisynthesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Mammalian AMP-activated protein kinase subfamily

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

21 January 2018

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AMPK in Health and Disease

21 January 2018

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CBS domains: structure, function, and pathology in human proteins

21 January 2018

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AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

AMPK is a direct adenylate charge-regulated protein kinase.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Structure of mammalian AMPK and its regulation by ADP

21 January 2018

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

21 January 2018

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Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.

21 January 2018

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Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

21 January 2018

1 reference

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Inhibition of the KCa3.1 channels by AMP-activated protein kinase in human airway epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Mechanistic insight into control of CFTR by AMPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

AMP-activated protein kinase inhibits TREK channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

AMP-activated protein kinase: also regulated by ADP?

21 January 2018

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

21 January 2018

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AMP-activated protein kinase modulators: a patent review (2006 - 2010).

21 January 2018

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Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

AMP-activated protein kinase and the regulation of glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.743994

10.1517/13543776.2012.743994

21 January 2018

Identifiers

DOI

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27 August 2017

1 reference