(Q37872742)

24 August 2017

1 reference

title

AMP-activated protein kinase modulators: a patent review (2006 - 2010). (English)

1 reference

24 August 2017

Hee Yun

1

1 reference

PubMed ID

21548715

24 August 2017

Joohun Ha

series ordinal

2

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PubMed ID

21548715

24 August 2017

language of work or name

English

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publication date

6 May 2011

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Expert Opinion on Therapeutic Patents

24 August 2017

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24 August 2017

21

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24 August 2017

7

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24 August 2017

983-1005

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AMPK: a key regulator of energy balance in the single cell and the whole organism.

24 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase as a drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Nutrition, metabolic factors and cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The AMP-activated protein kinase pathway--new players upstream and downstream.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The molecular basis and clinical aspects of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Autophagy in cancer: good, bad, or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Autophagy in metazoans: cell survival in the land of plenty

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Role of autophagy in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The P53 pathway: what questions remain to be explored?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Insulin-like growth factors and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Prevention of pancreatic cancer induction in hamsters by metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The exercise pill--too good to be true?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase plays a role in the control of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Defective lipid metabolism in the failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase in the heart: role during health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Mechanisms linking physical activity with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2011.577069

10.1517/13543776.2011.577069

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21548715