(Q38064172)

28 August 2017

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title

The role of BRCA1 in DNA double-strand repair: past and present (English)

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28 August 2017

Kevin W Caestecker

1

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28 August 2017

Gerlinde R Van de Walle

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

29 November 2012

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Experimental Cell Research

28 August 2017

published in

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28 August 2017

volume

319

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28 August 2017

issue

5

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28 August 2017

page(s)

575-587

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

28 August 2017

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The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

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BRCA1 protein products ... Functional motifs...

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Identification of a functional nuclear export sequence in BRCA1.

7 January 2021

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Localization of BRCA1 and a splice variant identifies the nuclear localization signal

7 January 2021

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BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions

7 January 2021

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Tracing the network connecting BRCA and Fanconi anaemia proteins

7 January 2021

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Genome maintenance mechanisms for preventing cancer

7 January 2021

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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

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Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.

7 January 2021

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The endless tale of non-homologous end-joining

7 January 2021

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Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

7 January 2021

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Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: the trans-S double-strand break repair model

7 January 2021

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Synapsis of DNA ends by DNA-dependent protein kinase

7 January 2021

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

7 January 2021

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The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

7 January 2021

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The DNA-polymerase-X family: controllers of DNA quality?

7 January 2021

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BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress

7 January 2021

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

7 January 2021

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

7 January 2021

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Cancer susceptibility and the functions of BRCA1 and BRCA2

7 January 2021

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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

7 January 2021

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Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor

7 January 2021

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

A computational method for the analysis and prediction of protein:phosphopeptide-binding sites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer

7 January 2021

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Function of TopBP1 in genome stability

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

7 January 2021

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ATR signalling: more than meeting at the fork

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

TopBP1 associates with NBS1 and is involved in homologous recombination repair.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The BRCT Domain Is a Phospho-Protein Binding Domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

7 January 2021

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BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

7 January 2021

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The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

PARP inhibition: PARP1 and beyond

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Assessing the link between BACH1 and BRCA1 in the FA pathway

7 January 2021

1 reference

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BACH1 is a DNA repair protein supporting BRCA1 damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 and BRCA2: 1994 and beyond

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Homologous recombination in DNA repair and DNA damage tolerance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The many interfaces of Mre11

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Histone ubiquitination associates with BRCA1-dependent DNA damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Association of BRCA1 with Rad51 in mitotic and meiotic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The emerging genetic and molecular basis of Fanconi anaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The epigenomics of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Identification of the breast cancer susceptibility gene BRCA2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Making the best of PARP inhibitors in ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Brca1 controls homology-directed DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Transcriptional activation by BRCA1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

BRCA1 interacts with components of the histone deacetylase complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Characterization of a carboxy-terminal BRCA1 interacting protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization and Recruitment to DNA Damage

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.11.013

10.1016/J.YEXCR.2012.11.013

7 January 2021

Identifiers

DOI

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28 August 2017

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