(Q38065955)

28 August 2017

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title

Proposed mechanism of off-target toxicity for antibody-drug conjugates driven by mannose receptor uptake (English)

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28 August 2017

Boris Gorovits

1

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28 August 2017

Corinna Krinos-Fiorotti

series ordinal

2

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28 August 2017

publication date

8 December 2012

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Cancer Immunology, Immunotherapy

28 August 2017

published in

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28 August 2017

volume

62

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28 August 2017

issue

2

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28 August 2017

page(s)

217-223

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https://scigraph.springernature.com/pub.10.1007/s00262-012-1369-3

28 August 2017

exact match

0 references

cites work

Evaluation of oligosaccharide methods for carbohydrate analysis in a fully human monoclonal antibody and comparison of the results to the monosaccharide composition determination by a novel calculation

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Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

21 January 2018

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From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor

21 January 2018

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Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys

21 January 2018

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The mannose receptor is expressed by subsets of APC in non-lymphoid organs

21 January 2018

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Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study

21 January 2018

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Mylotarg (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation

21 January 2018

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Phase I open study of the effects of ascending doses of the cytotoxic immunoconjugate CMB-401 (hCTMO1-calicheamicin) in patients with epithelial ovarian cancer

21 January 2018

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Capillary electrophoresis with laser-induced fluorescence detection for detailed studies on N-linked oligosaccharide profile of therapeutic recombinant monoclonal antibodies

21 January 2018

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A platform for high-throughput molecular characterization of recombinant monoclonal antibodies

21 January 2018

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The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

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Quantitation of the oligosaccharides of human serum IgG from patients with rheumatoid arthritis: a critical evaluation of different methods

21 January 2018

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Mannan binding lectin and its interaction with immunoglobulins in health and in disease.

21 January 2018

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21 January 2018

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The effect of Fc glycan forms on human IgG2 antibody clearance in humans

21 January 2018

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Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells

21 January 2018

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Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.

21 January 2018

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New and more efficient multivalent glyco-ligands for asialoglycoprotein receptor of mammalian hepatocytes

21 January 2018

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Arming antibodies: prospects and challenges for immunoconjugates

21 January 2018

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Potential use of immunoconjugates for AIDS therapy

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The low uptake of an abrin A-chain immunotoxin by rat hepatic cells in vivo and in vitro

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Hepatic sinusoidal obstruction after gemtuzumab ozogamicin (Mylotarg) therapy

21 January 2018

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High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

21 January 2018

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Increased serum clearance of oligomannose species present on a human IgG1 molecule

21 January 2018

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Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer.

21 January 2018

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Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers

21 January 2018

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10.1007/S00262-012-1369-3

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

28 August 2017

1051917958

0 references

1 reference