(Q38067063)

28 August 2017

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title

Protein arginine methyltransferases and cancer (English)

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28 August 2017

Yanzhong Yang

1

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28 August 2017

Mark T Bedford

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

13 December 2012

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28 August 2017

Nature Reviews Cancer

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28 August 2017

13

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28 August 2017

37-50

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28 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc3409

28 August 2017

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cites work

Protein arginine methylation in mammals: who, what, and why

1 reference

Distribution of NG, NG,-dimethylarginine in nuclear protein fractions

31 March 2020

1 reference

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

31 March 2020

1 reference

Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice.

31 March 2020

1 reference

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice

31 March 2020

1 reference

A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation

31 March 2020

1 reference

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

31 March 2020

1 reference

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

31 March 2020

1 reference

Arginine methylation of the histone H3 tail impedes effector binding

31 March 2020

1 reference

PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays

31 March 2020

1 reference

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.

31 March 2020

1 reference

PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins

31 March 2020

1 reference

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

31 March 2020

1 reference

Biochemical control of CARM1 enzymatic activity by phosphorylation

31 March 2020

1 reference

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1.

31 March 2020

1 reference

O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.

31 March 2020

1 reference

O-GlcNAc transferase regulates mitotic chromatin dynamics

31 March 2020

1 reference

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

31 March 2020

1 reference

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity

31 March 2020

1 reference

Automethylation of CARM1 allows coupling of transcription and mRNA splicing

31 March 2020

1 reference

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain

31 March 2020

1 reference

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

31 March 2020

1 reference

Crosstalk between CARM1 methylation and CBP acetylation on histone H3.

31 March 2020

1 reference

Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase

31 March 2020

1 reference

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

31 March 2020

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Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism

31 March 2020

1 reference

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

31 March 2020

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Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.

31 March 2020

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Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

31 March 2020

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The C-terminal domain of RNA polymerase II is modified by site-specific methylation

31 March 2020

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A novel WD repeat protein component of the methylosome binds Sm proteins

31 March 2020

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Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I.

31 March 2020

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Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase

31 March 2020

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The exon junction complex component Y14 modulates the activity of the methylosome in biogenesis of spliceosomal small nuclear ribonucleoproteins

31 March 2020

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RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

31 March 2020

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The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

31 March 2020

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Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

31 March 2020

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Methods and tips for the purification of human histone methyltransferases

31 March 2020

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A feedback regulatory loop between methyltransferase PRMT1 and orphan receptor TR3

31 March 2020

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hCAF1, a new regulator of PRMT1-dependent arginine methylation

31 March 2020

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The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase

31 March 2020

1 reference

A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity

31 March 2020

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DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo

31 March 2020

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A methylation-mediator complex in hormone signaling

31 March 2020

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The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation

31 March 2020

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PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family

31 March 2020

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The distribution and characterization of endogenous protein arginine N-methyltransferase 8 in mouse CNS.

31 March 2020

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Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization.

31 March 2020

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Nucleo-cytoplasmic shuttling of protein arginine methyltransferase 1 (PRMT1) requires enzymatic activity

31 March 2020

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Protein methylation and stress granules: posttranslational remodeler or innocent bystander?

31 March 2020

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Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells

31 March 2020

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Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

31 March 2020

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The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.

31 March 2020

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Deciphering arginine methylation: Tudor tells the tale.

31 March 2020

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Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

31 March 2020

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TDRD3 is an effector molecule for arginine-methylated histone marks

31 March 2020

1 reference

Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription

31 March 2020

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Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation

31 March 2020

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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

31 March 2020

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Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain

31 March 2020

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Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

31 March 2020

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Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

31 March 2020

1 reference

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

31 March 2020

1 reference

Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.

31 March 2020

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SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets

31 March 2020

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The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies

31 March 2020

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Tudor domains bind symmetrical dimethylated arginines

31 March 2020

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Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific manner

31 March 2020

1 reference

piRNAs and their involvement in male germline development in mice

31 March 2020

1 reference

Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability

31 March 2020

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Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

31 March 2020

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Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members

31 March 2020

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Tudor domain proteins in development

31 March 2020

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Non-coding RNAs in human disease

31 March 2020

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Piwis and piwi-interacting RNAs in the epigenetics of cancer

31 March 2020

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Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer

31 March 2020

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Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi

31 March 2020

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Precancerous stem cells have the potential for both benign and malignant differentiation

31 March 2020

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Stress granules: the Tao of RNA triage

31 March 2020

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Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.

31 March 2020

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The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor

31 March 2020

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Survival motor neuron protein facilitates assembly of stress granules

31 March 2020

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TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules

31 March 2020

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Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.

31 March 2020

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Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

31 March 2020

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Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

31 March 2020

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PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells

31 March 2020

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Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

31 March 2020

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Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

31 March 2020

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Global histone modification patterns predict risk of prostate cancer recurrence

31 March 2020

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Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray.

31 March 2020

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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

31 March 2020

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The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity

31 March 2020

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Purification of proteins associated with specific genomic Loci

31 March 2020

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Arginine methylation regulates telomere length and stability.

31 March 2020

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Regulation of estrogen rapid signaling through arginine methylation by PRMT1

31 March 2020

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Methylation, a key step for nongenomic estrogen signaling in breast tumors

31 March 2020

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Drugging Wnt signalling in cancer

31 March 2020

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Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

31 March 2020

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Protein arginine-methyltransferase-dependent oncogenesis

31 March 2020

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PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential

31 March 2020

1 reference

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

31 March 2020

1 reference

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

31 March 2020

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PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

31 March 2020

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Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma

31 March 2020

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Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer

31 March 2020

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beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2

31 March 2020

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The arginine methyltransferase PRMT2 binds RB and regulates E2F function

31 March 2020

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Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

31 March 2020

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Proteomic dissection of the von Hippel-Lindau (VHL) interactome

31 March 2020

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Genetic and molecular alterations in meningiomas.

31 March 2020

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Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer.

31 March 2020

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Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer

31 March 2020

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Regulation of transcription by a protein methyltransferase

31 March 2020

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Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene

31 March 2020

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Roles of protein arginine methylation in DNA damage signaling pathways is CARM1 a life-or-death decision point?

31 March 2020

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Coactivator function defines the active estrogen receptor alpha cistrome

31 March 2020

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Methylation of histone H3 by coactivator-associated arginine methyltransferase 1

31 March 2020

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CARM1 mediates modulation of Sox2.

31 March 2020

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Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin

31 March 2020

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The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation

31 March 2020

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Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly

31 March 2020

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Control of CBP co-activating activity by arginine methylation

31 March 2020

1 reference

Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status

31 March 2020

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Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

31 March 2020

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CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells

31 March 2020

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The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer.

31 March 2020

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CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.

31 March 2020

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A transcriptional switch mediated by cofactor methylation

31 March 2020

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Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

31 March 2020

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A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression.

31 March 2020

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Differential CARM1 expression in prostate and colorectal cancers

31 March 2020

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Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes

31 March 2020

1 reference

Matrix metalloproteinases: regulators of the tumor microenvironment

31 March 2020

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Transcriptional activation of human matrix metalloproteinase-9 gene expression by multiple co-activators

31 March 2020

1 reference

Negative regulation of transcription by the type II arginine methyltransferase PRMT5

31 March 2020

1 reference

The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression

31 March 2020

1 reference

HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules

31 March 2020

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Arginine methylation controls growth regulation by E2F-1

31 March 2020

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A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage

31 March 2020

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Arginine methylation regulates the p53 response

31 March 2020

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Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.

31 March 2020

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PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

31 March 2020

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p53 methylation--the Arg-ument is clear

31 March 2020

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The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

31 March 2020

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Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

31 March 2020

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Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

31 March 2020

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Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF

31 March 2020

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A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

31 March 2020

1 reference

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

31 March 2020

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Arginine methylation regulates DNA polymerase beta

31 March 2020

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Protein arginine methyltransferase 6 regulates multiple aspects of gene expression

31 March 2020

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Thrombospondin-1 is a transcriptional repression target of PRMT6.

31 March 2020

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Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors

31 March 2020

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Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor

31 March 2020

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The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes

31 March 2020

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Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis

31 March 2020

1 reference

BORIS in human cancers -- a review

31 March 2020

1 reference

Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1

31 March 2020

1 reference

Protein arginine (N)-methyl transferase 7 (PRMT7) as a potential target for the sensitization of tumor cells to camptothecins

31 March 2020

1 reference

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

31 March 2020

1 reference

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

31 March 2020

1 reference

JMJD6 is a histone arginine demethylase

31 March 2020

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Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

31 March 2020

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Interaction of JMJD6 with single-stranded RNA

31 March 2020

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Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

31 March 2020

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Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation

31 March 2020

1 reference

Targets in epigenetics: inhibiting the methyl writers of the histone code

31 March 2020

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Current chemical biology approaches to interrogate protein methyltransferases

31 March 2020

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

31 March 2020

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Selective inhibition of BET bromodomains

31 March 2020

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

31 March 2020

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

31 March 2020

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Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains

31 March 2020

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Histone arginine methylation

31 March 2020

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Methylation of H2AR29 is a novel repressive PRMT6 target

31 March 2020

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Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

31 March 2020

1 reference

The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation

31 March 2020

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Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable

31 March 2020

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Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation

31 March 2020

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Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification

31 March 2020

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Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions

31 March 2020

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Enzymatic activity is required for the in vivo functions of CARM1.

31 March 2020

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Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development

31 March 2020

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CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

31 March 2020

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CARM1 promotes adipocyte differentiation by coactivating PPARgamma

31 March 2020

1 reference

Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes

31 March 2020

1 reference

Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function

31 March 2020

1 reference

The PRMT1 gene expression pattern in colon cancer

31 March 2020

1 reference

Clinical evaluation of PRMT1 gene expression in breast cancer

31 March 2020

1 reference

Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia

31 March 2020

1 reference

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

31 March 2020

1 reference

Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23235912

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Colon cancer and protein arginine methyltransferase 1 gene expression.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23235912

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

JAK-mutant myeloproliferative neoplasms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23235912

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC3409

1 reference

Dimensions Publication ID

28 August 2017

0 references

1 reference