(Q38075894)

28 August 2017

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title

The serrated pathway to colorectal carcinoma: current concepts and challenges (English)

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28 August 2017

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Andrew Clouston

3

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author name string

Mark Bettington

1

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28 August 2017

Neal Walker

2

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28 August 2017

Ian Brown

4

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28 August 2017

Barbara Leggett

5

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28 August 2017

Vicki Whitehall

6

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28 August 2017

publication date

1 February 2013

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28 August 2017

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28 August 2017

volume

62

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28 August 2017

issue

3

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28 August 2017

page(s)

367-386

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Classification of colorectal cancer based on correlation of clinical, morphological and molecular features

28 August 2017

cites work

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Update on the serrated pathway to colorectal carcinoma

21 January 2018

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Genetic alterations during colorectal-tumor development

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Serrated adenomatous polyposis in humans.

21 January 2018

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

21 January 2018

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Clues to the pathogenesis of familial colorectal cancer

21 January 2018

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Microsatellite instability in cancer of the proximal colon

21 January 2018

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

21 January 2018

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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

21 January 2018

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Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

21 January 2018

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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

21 January 2018

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Mutation of a mutL homolog in hereditary colon cancer

21 January 2018

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CpG islands in vertebrate genomes

21 January 2018

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CpG-rich islands and the function of DNA methylation

21 January 2018

1 reference

CpG island methylator phenotype in colorectal cancer

21 January 2018

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

21 January 2018

1 reference

DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

21 January 2018

1 reference

Colorectal serrated adenocarcinoma

21 January 2018

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RAF/RAS oncogenes and mismatch-repair status

21 January 2018

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Morphologic reappraisal of serrated colorectal polyps.

21 January 2018

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High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.

21 January 2018

1 reference

Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma.

21 January 2018

1 reference

Pathologic features and biologic importance of colorectal serrated polyps

21 January 2018

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Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society

21 January 2018

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Hyperplastic and serrated polyps of the colorectum.

21 January 2018

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Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.

21 January 2018

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Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.

21 January 2018

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MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6.

21 January 2018

1 reference

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

21 January 2018

1 reference

Tumour biology: senescence in premalignant tumours

21 January 2018

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Cellular senescence in cancer and aging

21 January 2018

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Cellular senescence: when bad things happen to good cells

21 January 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

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Apoptosis index and apoptosis-related antigen expression in serrated adenoma of the colorectum: the saw-toothed structure may be related to inhibition of apoptosis

21 January 2018

1 reference

Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients.

21 January 2018

1 reference

A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma.

21 January 2018

1 reference

Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria

21 January 2018

1 reference

Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management

21 January 2018

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Sessile serrated adenomas: high-risk lesions?

21 January 2018

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Sessile serrated lesion and its borderline variant - Variables with impact on recorded data

21 January 2018

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Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer

21 January 2018

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Role of the serrated pathway in colorectal cancer pathogenesis

21 January 2018

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

21 January 2018

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Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation

21 January 2018

1 reference

Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.

21 January 2018

1 reference

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

21 January 2018

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Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points

21 January 2018

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Filiform serrated adenoma is an unusual, less aggressive variant of traditional serrated adenoma.

21 January 2018

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Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases.

21 January 2018

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CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.

21 January 2018

1 reference

Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study

21 January 2018

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Histologic and molecular analyses of colonic perineurial-like proliferations in serrated polyps: perineurial-like stromal proliferations are seen in sessile serrated adenomas.

21 January 2018

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Morphology of sporadic colorectal cancer with DNA replication errors

21 January 2018

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Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study

21 January 2018

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Histopathological identification of colon cancer with microsatellite instability

21 January 2018

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Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

21 January 2018

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Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

21 January 2018

1 reference

Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer

21 January 2018

1 reference

BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features.

21 January 2018

1 reference

p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers

21 January 2018

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Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer

21 January 2018

1 reference

Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases

21 January 2018

1 reference

Three DNA methylation epigenotypes in human colorectal cancer

21 January 2018

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Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.

21 January 2018

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CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations

21 January 2018

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Sialic acid and epithelial differentiation in colorectal polyps and cancer — A morphological, mucin and lectin histochemical study

21 January 2018

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Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer.

21 January 2018

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Clinicopathologic study of 85 colorectal serrated adenocarcinomas: further insights into the full recognition of a new subset of colorectal carcinoma.

21 January 2018

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Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma.

21 January 2018

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

21 January 2018

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

21 January 2018

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

21 January 2018

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Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

21 January 2018

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A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/HIS.12055

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28 August 2017

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