(Q38079390)

28 August 2017

title

Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world (English)

1 reference

28 August 2017

Jillian M Hagel

1

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28 August 2017

Peter J Facchini

series ordinal

2

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28 August 2017

publication date

5 February 2013

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Plant and Cell Physiology

28 August 2017

number of pages

26

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based on heuristic

inferred from page(s)

published in

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28 August 2017

volume

54

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28 August 2017

issue

5

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28 August 2017

page(s)

647-672

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RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy

28 August 2017

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21 January 2018

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444. Investigations on the biosynthesis of morphine alkaloids

21 January 2018

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21 January 2018

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21 January 2018

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Biosynthesis of unnatural papaverine derivatives in Papaver somniferum.

21 January 2018

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Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica.

21 January 2018

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Acyltransferases in plants: a good time to be BAHD.

21 January 2018

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Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy

21 January 2018

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Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.

21 January 2018

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Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia

21 January 2018

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Mining the biodiversity of plants: a revolution in the making

21 January 2018

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Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy.

21 January 2018

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Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures

21 January 2018

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Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana

21 January 2018

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Available and future treatments for erectile dysfunction

21 January 2018

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Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack

21 January 2018

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Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts.

21 January 2018

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Synthetic biosystems for the production of high-value plant metabolites.

21 January 2018

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Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants

21 January 2018

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Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy

21 January 2018

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Molecular characterization of berberine bridge enzyme genes from opium poppy

21 January 2018

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Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids

21 January 2018

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Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots

21 January 2018

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Metabolic engineering with a morphine biosynthetic P450 in opium poppy surpasses breeding

21 January 2018

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Comparative qualitative and quantitative determination of alkaloids in narcotic and condiment Papaver somniferum cultivars

21 January 2018

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Molecular cloning and functional expression of O-methyltransferases common to isoquinoline alkaloid and phenylpropanoid biosynthesis

21 January 2018

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Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells.

21 January 2018

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Application of an integrated LC-UV-MS-NMR platform to the identification of secondary metabolites from cell cultures: benzophenanthridine alkaloids from elicited Eschscholzia californica (california poppy) cell cultures().

21 January 2018

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Heterologous expression of two FAD-dependent oxidases with (S)-tetrahydroprotoberberine oxidase activity from Arge mone mexicana and Berberis wilsoniae in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy

21 January 2018

1 reference

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Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular characterization of the salutaridinol 7-O-acetyltransferase involved in morphine biosynthesis in opium poppy Papaver somniferum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Quaternary protoberberine alkaloids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Quantitative 1H nuclear magnetic resonance metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy

21 January 2018

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The biosynthesis of papaverine proceeds via (S)-reticuline

21 January 2018

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Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

21 January 2018

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Atomic Structure of Salutaridine Reductase from the Opium Poppy (Papaver somniferum)

21 January 2018

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Virus-induced gene silencing is an effective tool for assaying gene function in the basal eudicot species Papaver somniferum (opium poppy).

21 January 2018

1 reference

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1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway

21 January 2018

1 reference

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Immunoblot analyses of the elicited Sanguinaria canadensis enzyme, dihydrobenzophenanthridine oxidase: evidence for resolution from a polyphenol oxidase isozyme.

21 January 2018

1 reference

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Molecular cloning and characterization of methylenedioxy bridge-forming enzymes involved in stylopine biosynthesis in Eschscholzia californica.

21 January 2018

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Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.

21 January 2018

1 reference

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Structural basis of enzymatic (S)-norcoclaurine biosynthesis

21 January 2018

1 reference

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Overexpression of Coptis japonica norcoclaurine 6-O-methyltransferase overcomes the rate-limiting step in Benzylisoquinoline alkaloid biosynthesis in cultured Eschscholzia californica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase in transgenic Coptis japonica plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Manufacturing molecules through metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

RNAi suppression of the morphine biosynthetic gene salAT and evidence of association of pathway enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Biosynthesis of the Morphine Alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and heterologous expression of a cDNA encoding berbamunine synthase, a C--O phenol-coupling cytochrome P450 from the higher plant Berberis stolonifera

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Tyrosine aminotransferase contributes to benzylisoquinoline alkaloid biosynthesis in opium poppy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Evidence for the monophyletic evolution of benzylisoquinoline alkaloid biosynthesis in angiosperms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N-methyltransferases from three benzylisoquinoline alkaloid-producing species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Analgesia: morphine-pathway block in top1 poppies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Microbial production of plant benzylisoquinoline alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

A bacterial platform for fermentative production of plant alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Proteomic analysis of Chelidonium majus milky sap using two-dimensional gel electrophoresis and tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Shotgun Proteomic Analysis of Yeast-Elicited California Poppy (Eschscholzia californica) Suspension Cultures Producing Enhanced Levels of Benzophenanthridine Alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Über die Bildung von Isochinolin-derivaten durch Einwirkung von Methylal auf Phenyl-äthylamin, Phenyl-alanin und Tyrosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Canadine synthase from Thalictrum tuberosum cell cultures catalyses the formation of the methylenedioxy bridge in berberine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Biocatalytic production of tetrahydroisoquinolines

21 January 2018

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Integrating carbon-halogen bond formation into medicinal plant metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Partial purification and characterization of dihydrobenzophenanthridine oxidase from Eschscholtzia californica cell suspension cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Consumption of bitter alkaloids in Drosophila melanogaster in multiple-choice test conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

21 January 2018

Epidemic dropsy in India

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

The effect of varying alkaloid concentrations on the feeding behavior of gypsy moth larvae, Lymantria dispar (L.) (Lepidoptera: Lymantriidae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Chemical ecological characteristics of herbivory of Siparuna guianensis seeds by buffy-headed marmosets (Callithrix flaviceps) in the Atlantic Forest of southeastern Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

BIAdb: a curated database of benzylisoquinoline alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Identification and quantification of isoquinoline alkaloids in the genus Sarcocapnos by GC-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Studies on the early stages of Papaver alkaloid biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

A concerted mechanism for berberine bridge enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Isoquinoline alkaloid biosynthesis is regulated by a unique bHLH-type transcription factor in Coptis japonica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Evolution and current status of the phytochemistry of nitrogenous compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Alkaloid biosynthesis: metabolism and trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

Biosynthesis of Hydrastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPCP%2FPCT020

A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline

21 January 2018

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.1002/JLAC.1990199001104

Biosynthesis of Benzo[c]phenanthridine Alkaloids Sanguinarine, Chelirubine and Macarpine

9 March 2024

1 reference

9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/HLCA.19830660208

Identifiers

DOI

10.1093/PCP/PCT020

1 reference

28 August 2017

1 reference