(Q38084455)

English

Fluid-phase pinocytosis of LDL by macrophages: a novel target to reduce macrophage cholesterol accumulation in atherosclerotic lesions

scientific article published on January 2013

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scholarly article

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

Fluid-phase pinocytosis of LDL by macrophages: a novel target to reduce macrophage cholesterol accumulation in atherosclerotic lesions (English)

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

0 references

atherosclerosis

1 reference

based on heuristic

inferred from title

author name string

Howar S Kruth

1

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

publication date

1 January 2013

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

Current Pharmaceutical Design

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

19

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

33

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

5865-5872

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large variations in human foam cell formation in individuals: a fully autologous in vitro assay based on the quantitative analysis of cellular neutral lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of foam cell formation: modified LDL stimulates uptake of co-incubated LDL via macropinocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of macropinocytosis by p21-activated kinase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origin, originality, functions, subversions and molecular signalling of macropinocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage foam cell formation with native low density lipoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macropinocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective catabolism of oxidized LDL by J774 murine macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver X receptors as integrators of metabolic and inflammatory signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive receptor-independent low density lipoprotein uptake and cholesterol accumulation by macrophages differentiated from human monocytes with macrophage-colony-stimulating factor (M-CSF)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C β and δ isoenzymes mediate cholesterol accumulation in PMA-activated macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Src-family kinases in formation and trafficking of macropinosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of human macrophages in culture and in atherosclerotic plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macropinocytosis contributes to the macrophage foam cell formation in RAW264.7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apo B concentration in the normal human aorta

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoprotein degradation and cholesterol esterification in primary cell cultures of rabbit atherosclerotic lesions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport, interactions and retention of plasma proteins in the intima: the barrier function of the internal elastic lamina

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol esters stimulate macropinocytosis and solute flow through macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-density lipoprotein concentration in interstitial fluid from human atherosclerotic lesions. Relation to theories of endothelial damage and lipoprotein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low density lipoprotein receptor activity in human monocyte-derived macrophages and its relation to atheromatous lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the metabolism of modified and unmodified low-density lipoproteins during the maturation of cultured blood monocyte-macrophages from normal and homozygous familial hypercholesterolaemic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of oxidized lipoproteins in atherogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of macropinocytosis in v-Src-transformed fibroblasts: cyclic AMP selectively promotes regurgitation of macropinosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23438954

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2174/1381612811319330005

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

1 reference

Europe PubMed Central

30 June 2019

http://europepmc.org/abstract/PMC/6561333

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