(Q38088316)

28 August 2017

title

Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discovery (English)

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28 August 2017

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Doru Georg Margineanu

series ordinal

1

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28 August 2017

Henrik Klitgaard

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

1 January 2009

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

4

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28 August 2017

issue

1

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28 August 2017

page(s)

23-32

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Seizure remission in adults with intractable epilepsy: not just a pipe dream

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Antiepileptic drugs in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Early identification of refractory epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

A brief history of epilepsy and its therapy in the Western Hemisphere

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The new antiepileptic drugs: scientific review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Refractory epilepsy: clinical overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Pharmacoresistance: modern concept and basic data derived from human brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Molecular and cellular mechanisms of pharmacoresistance in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Clinical aspects and biological bases of drug-resistant epilepsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Drug resistance in brain diseases and the role of drug efflux transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Drug transporters in the epileptic brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Plasticity of antiepileptic drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Refractory epilepsy: mechanisms and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Anticonvulsant mechanisms of the ketogenic diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Long-term outcomes in epilepsy surgery: antiepileptic drugs, mortality, cognitive and psychosocial aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Vagus nerve stimulation for the treatment of intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Brain stimulation for epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Neurostimulation therapy for epilepsy: current modalities and future directions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Cell and gene therapies for refractory epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Cell and gene therapies in epilepsy--promising avenues or blind alleys?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Cellular and molecular mechanisms of epilepsy in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Neuroplasticity in the damaged dentate gyrus of the epileptic brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The blood-brain barrier and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

New facets of the neuropathology and molecular profile of human temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The neurobiology of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The neurobiology of antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

21 January 2018

Ion channels in epilepsy

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

GABAergic mechanisms in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The new antiepileptic drugs: clinical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Current status and future directions in the pharmacotherapy of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Mechanisms of antiepileptic drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

A novel mechanism underlying drug resistance in chronic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Brain inflammation in epilepsy: experimental and clinical evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Differential neuronal and glial relations with parameters of ictal discharge in mesial temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Astrocytes, from brain glue to communication elements: the revolution continues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Expression and functions of neuronal gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Life cycle of connexins in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Gap junctions and connexin expression in the normal and pathological central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Multidrug resistance in cancer: its mechanism and its modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Clinical aspects of the ketogenic diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

The adult human brain in preclinical drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Antiepileptic drug discovery: lessons from the past and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440802611729

10.1517/17460440802611729

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference