(Q38088781)

28 August 2017

Thermodynamics of binding interactions in the rational drug design process (English)

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28 August 2017

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Geoff A Holdgate

1

1 reference

PubMed ID

23484875

28 August 2017

language of work or name

English

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publication date

1 August 2007

1 reference

Expert Opinion on Drug Discovery

28 August 2017

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28 August 2017

2

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28 August 2017

1103-1114

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28 August 2017

8

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Heat capacity and entropy changes in processes involving proteins

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Thermodynamics of buried water clusters at a protein-ligand binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Uses of enthalpy–entropy compensation in protein research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Enthalpy-entropy compensation is not a general feature of weak association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Hydrophobic effect in protein folding and other noncovalent processes involving proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Measurements of binding thermodynamics in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

The development of a continuous isothermal titration calorimetric method for equilibrium studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

On the value of c: can low affinity systems be studied by isothermal titration calorimetry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

ITC in the post-genomic era...? Priceless

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Isothermal titration calorimetry to determine association constants for high-affinity ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

A study of statistical error in isothermal titration calorimetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Calibration in isothermal titration calorimetry: heat and cell volume from heat of dilution of NaCl(aq).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Analysis of ligand binding by bioaffinity mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Frontal affinity chromatography combined on-line with mass spectrometry: a tool for the binding study of different epidermal growth factor receptor inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Recent advances in the study of biomolecular interactions by capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

A thermodynamic characterization of the binding of thrombin inhibitors to human thrombin, combining biosensor technology, stopped-flow spectrophotometry, and microcalorimetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Towards predictive ligand design with free-energy based computational methods?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Universal screening methods and applications of ThermoFluor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Thermofluor-based high-throughput stability optimization of proteins for structural studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Differential scanning calorimetry in life science: thermodynamics, stability, molecular recognition and application in drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Applications of calorimetric methods to drug discovery and the study of protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Biochemical characterization of a phosphinate inhibitor of Escherichia coli MurC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Binding thermodynamics of statins to HMG-CoA reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Advances in membrane receptor screening and analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Investigation of ligand binding to the multidrug resistance protein EmrE by isothermal titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

Thermodynamics of the cyclophilin-A/cyclosporin-A interaction: A direct comparison of parameters determined by surface plasmon resonance using Biacore T100 and isothermal titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.8.1103

10.1517/17460441.2.8.1103

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23484875