(Q38088809)

28 August 2017

title

Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes (English)

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28 August 2017

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Malin Kb Jonsson

1

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28 August 2017

Toon Ab van Veen

2

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28 August 2017

Marie-Jose Goumans

3

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28 August 2017

Marc A Vos

4

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28 August 2017

Göran Duker

5

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28 August 2017

Peter Sartipy

6

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28 August 2017

language of work or name

English

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publication date

1 April 2009

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

4

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28 August 2017

issue

4

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28 August 2017

page(s)

357-372

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Can the pharmaceutical industry reduce attrition rates?

28 August 2017

cites work

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Can human embryonic stem cells contribute to the discovery of safer and more effective drugs?

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Embryonic stem cells as a source of models for drug discovery.

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Properties of a clonal muscle cell line from rat heart

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HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

21 January 2018

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Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

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21 January 2018

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Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block.

21 January 2018

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The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

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Molecular basis of species-specific expression of repolarizing K+ currents in the heart.

21 January 2018

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In vitro and in vivo models for testing arrhythmogenesis in drugs

21 January 2018

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Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability

21 January 2018

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Cardiac HCN channels: structure, function, and modulation

21 January 2018

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Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function

21 January 2018

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Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome

21 January 2018

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Drug-induced QT dispersion: does it predict the risk of torsade de pointes?

21 January 2018

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Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs

21 January 2018

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Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

21 January 2018

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Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall

21 January 2018

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21 January 2018

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In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience

21 January 2018

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Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

21 January 2018

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Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Heterogeneity and cardiac arrhythmias: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Cell-based assays for high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

Molecular and pharmacological properties of human embryonic stem cell-derived cardiomyocytes

21 January 2018

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Embryonic stem cells for cardiac muscle engineering

21 January 2018

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Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

3D-model of adult cardiac stem cells promotes cardiac differentiation and resistance to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Tissue engineering of vascularized cardiac muscle from human embryonic stem cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

Embryonic stem cell lines derived from human blastocysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Adaptation of human embryonic stem cells to feeder-free and matrix-free culture conditions directly on plastic surfaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Enhanced differentiation of human embryonic stem cells into cardiomyocytes by combining hanging drop culture and 5-azacytidine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902794912

Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Transgenic enrichment of cardiomyocytes from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

A lentiviral vector with a short troponin-I promoter for tracking cardiomyocyte differentiation of human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Identification and selection of cardiomyocytes during human embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Selection of ventricular-like cardiomyocytes from ES cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Improved genetic manipulation of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Electrophysiological properties of pluripotent human and mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Adult cardiac stem cells are multipotent and support myocardial regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

The post-natal heart contains a myocardial stem cell population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Endogenous cardiac stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Cardiac regeneration by resident stem and progenitor cells in the adult heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Isolation and expansion of resident cardiac progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Generation of germline-competent induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Generation of human induced pluripotent stem cells from dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Reprogramming of human somatic cells to pluripotency with defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Pluripotent stem cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Disease-specific induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Generation of insulin-secreting islet-like clusters from human skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Generation of functional murine cardiac myocytes from induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Skeletal myoblasts as a therapeutic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Myocardial regeneration with bone-marrow-derived stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

The effect of cyclic strain on embryonic stem cell-derived cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

A model for human ventricular tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902794912

10.1517/17460440902794912

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference