(Q38094906)

28 August 2017

Biologic agents in osteoarthritis: hopes and disappointments (English)

1 reference

28 August 2017

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Xavier Chevalier

1

1 reference

28 August 2017

Florent Eymard

series ordinal

2

1 reference

28 August 2017

Pascal Richette

series ordinal

3

1 reference

28 August 2017

language of work or name

English

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publication date

2 April 2013

1 reference

Nature Reviews Rheumatology

28 August 2017

1 reference

28 August 2017

9

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28 August 2017

7

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28 August 2017

400-410

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2013.44

28 August 2017

0 references

cites work

Osteoarthritis: new insights. Part 1: the disease and its risk factors.

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoarthritis: an update with relevance for clinical practice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Obesity and osteoarthritis: more complex than predicted!

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Upregulation of enzymatic activity by interleukin-1 in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Synovial tissue inflammation in early and late osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Activated synovial macrophages as targets for osteoarthritis drug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The diagnostic performance of MRI in osteoarthritis: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoarthritis, angiogenesis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteochondral plate angiogenesis: a new treatment target in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Cytokines as therapeutic targets for osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Cytokine targeting in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Biologics in development for rheumatoid arthritis: relevance to osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Intraarticular treatments for osteoarthritis: new perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Nerve growth factor: A key local regulator in the pathogenesis of inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

NGF - the TrkA to successful pain treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Tanezumab for the treatment of pain from osteoarthritis of the knee.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Control of arthritis pain with anti-nerve-growth factor: risk and benefit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Desperately looking for the right target in osteoarthritis: the anti-IL-1 strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Erosive osteoarthritis of the hand: clinical experience with anakinra

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

21 January 2018

Erosive osteoarthritis

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Value of C reactive protein in the assessment of erosive osteoarthritis of the hand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Assessing health-related quality of life in hand osteoarthritis: a literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Patients' perceptions of the treatment and management of hand osteoarthritis: a focus group enquiry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoarthritis of the knee: comparison of MR imaging findings with radiographic severity measurements and pain in middle-aged women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Measures of social function and participation in musculoskeletal populations: Impact on Participation and Autonomy (IPA), Keele Assessment of Participation (KAP), Participation Measure for Post-Acute Care (PM-PAC), Participation Objective, Participa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The role of nitric oxide in tissue destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Recent advances in BMP receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Overview of bone morphogenetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The effect of growth factor treatment on meniscal chondrocyte proliferation and differentiation on polyglycolic acid scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteophytes: relevance and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Pharmacologic therapy for osteoarthritis--the era of disease modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The role of synovitis in osteoarthritis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Are we moving in the right direction with osteoarthritis drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

The role of cytokines in cartilage matrix degeneration in osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Nerve growth factor and pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Nerve growth factor concentrations in the synovial fluid from healthy dogs and dogs with secondary osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Efficacy and safety of tanezumab in the treatment of chronic low back pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Clinical benefits of intra-articular anakinra for persistent knee effusion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Efficacy of infliximab in a rabbit model of osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteoarthritis: best evidence for best therapies in hand osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Edema of the bone marrow can cause pain in osteoarthritis and other diseases of bone and joints

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.44

Osteogenic protein-1: biology and applications

31 March 2020

1 reference

12 December 2020

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid

1 reference

12 December 2020

Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer.

1 reference

12 December 2020

JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical

1 reference

12 December 2020

[Physiopathogenesis of osteoarthritis. The arthritis cartilage]

1 reference

12 December 2020

A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands

1 reference

12 December 2020

Intra-articular administration of interleukin-1 causes prolonged suppression of cartilage proteoglycan synthesis in rats

1 reference

12 December 2020

DMOAD developments: present and future

1 reference

12 December 2020

A high interleukin 1 receptor antagonist/IL-1beta ratio occurs naturally in knee osteoarthritis

1 reference

12 December 2020

Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study

1 reference

12 December 2020

[Targeted anti-cytokine therapies for osteoarthritis]

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2013.44

1 reference

Dimensions Publication ID

28 August 2017

0 references

1 reference