(Q38097076)

28 August 2017

title

Aldehyde oxidase and its importance in novel drug discovery: present and future challenges (English)

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28 August 2017

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Enrico Garattini

1

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28 August 2017

Mineko Terao

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

9 April 2013

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

8

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28 August 2017

issue

6

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28 August 2017

page(s)

641-654

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Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Mammalian aldehyde oxidases: genetics, evolution and biochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Aldehyde oxidase: an enzyme of emerging importance in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Discovery of a highly potent series of TLR7 agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Human liver aldehyde oxidase: inhibition by 239 drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Purification of hepatic xanthine dehydrogenase from chicken fed a high-protein diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Crystal structures of heme binding protein 23 and xanthine dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The role of aldehyde oxidase in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The xanthine oxidoreductase gene: structure and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Chromosomal mapping, isolation, and characterization of the mouse xanthine dehydrogenase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The dual substrate specificity of aldehyde oxidase 1 for retinal and acetaldehyde and its role in ABCA1 mediated efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Substrate specificity of rabbit aldehyde oxidase for nitroguanidine and nitromethylene neonicotinoid insecticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Potent inhibition of human liver aldehyde oxidase by raloxifene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Drugs that inhibit oxidation reactions catalyzed by aldehyde oxidase do not inhibit the reductive metabolism of ziprasidone to its major metabolite, S-methyldihydroziprasidone: an in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Biotransformation of carbazeran in guinea pig: effect of hydralazine pretreatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

In vivo-in vitro relationship of methotrexate 7-hydroxylation by aldehyde oxidase in four different strain rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The biotransformation of nitrogen containing xenobiotics to lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

The impact of single nucleotide polymorphisms on human aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Species variation in hepatic aldehyde oxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Molybdenum(VI) salts convert the xanthine oxidoreductase apoprotein into the active enzyme in mouse L929 fibroblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

Characterization and Crystallization of Mouse Aldehyde Oxidase 3: From Mouse Liver to Escherichia coli Heterologous Protein Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.788497

10.1517/17460441.2013.788497

21 January 2018

Identifiers

DOI

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28 August 2017

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