(Q38101307)

28 August 2017

Genome-scale modeling of human metabolism - a systems biology approach (English)

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28 August 2017

3

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28 August 2017

Francesco Gatto

2

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author name string

Adil Mardinoglu

series ordinal

1

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28 August 2017

24 April 2013

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28 August 2017

Biotechnology Journal

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28 August 2017

8

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28 August 2017

985-996

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28 August 2017

9

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Cellular metabolism and disease: what do metabolic outliers teach us?

28 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk

21 January 2018

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Endoplasmic reticulum stress and inflammation in obesity and diabetes

21 January 2018

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Systems biology of lipid metabolism: from yeast to human

21 January 2018

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A protocol for generating a high-quality genome-scale metabolic reconstruction

21 January 2018

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Systems medicine and metabolic modelling

21 January 2018

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Blueprint for antimicrobial hit discovery targeting metabolic networks

21 January 2018

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Network medicine: a network-based approach to human disease

21 January 2018

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Systems biology: a brief overview

21 January 2018

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Genome-scale models of microbial cells: evaluating the consequences of constraints

21 January 2018

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

The Edinburgh human metabolic network reconstruction and its functional analysis

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Compartmentalization of the Edinburgh Human Metabolic Network

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

KEGG for representation and analysis of molecular networks involving diseases and drugs

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT

21 January 2018

1 reference

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Integration of clinical data with a genome-scale metabolic model of the human adipocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Reactome: a database of reactions, pathways and biological processes

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Applications of mass spectrometry to lipids and membranes

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Computational prediction of human metabolic pathways from the complete human genome

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

ChEBI: a database and ontology for chemical entities of biological interest

21 January 2018

1 reference

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Ongoing and future developments at the Universal Protein Resource

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

LMPD: LIPID MAPS proteome database

21 January 2018

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Creation of an antibody-based subcellular protein atlas

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Optimization based automated curation of metabolic reconstructions

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Integration of gene expression data into genome-scale metabolic models

21 January 2018

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Context-specific metabolic networks are consistent with experiments

21 January 2018

1 reference

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Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism

21 January 2018

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Functional integration of a metabolic network model and expression data without arbitrary thresholding.

21 January 2018

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Predicting metabolic fluxes using gene expression differences as constraints.

21 January 2018

1 reference

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Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation

21 January 2018

1 reference

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Mechanistic systems modeling to guide drug discovery and development

21 January 2018

1 reference

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A gene atlas of the mouse and human protein-encoding transcriptomes

21 January 2018

1 reference

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HMDB: the Human Metabolome Database

21 January 2018

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Drug off-target effects predicted using structural analysis in the context of a metabolic network model

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Large-scale in silico modeling of metabolic interactions between cell types in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism

21 January 2018

1 reference

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A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

21 January 2018

1 reference

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Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Regulation of cancer cell metabolism

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Therapeutic targets in cancer cell metabolism and autophagy

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling

21 January 2018

1 reference

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Cancer. Systems biology, metabolomics, and cancer metabolism

21 January 2018

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

21 January 2018

1 reference

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Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Uncovering transcriptional regulation of metabolism by using metabolic network topology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Messy biology and the origins of evolutionary innovations

21 January 2018

1 reference

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Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model

21 January 2018

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Differential network biology

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Metabolic systems biology

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Integration of expression data in genome-scale metabolic network reconstructions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

What is flux balance analysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli

21 January 2018

1 reference

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Metabolic networks in motion: 13C-based flux analysis

21 January 2018

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201200275

Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes

21 January 2018

1 reference

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Systems biology as a foundation for genome-scale synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

It is all about metabolic fluxes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

1 reference

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Enzymatic features of the glucose metabolism in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Systems biology, metabolic modelling and metabolomics in drug discovery and development

21 January 2018

1 reference

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Bioinformatic-driven search for metabolic biomarkers in disease

21 January 2018

1 reference

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The role of metabolic biomarkers in drug toxicity studies

21 January 2018

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Biomarkers and immune-modulating therapies for type 2 diabetes

21 January 2018

1 reference

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Predicting metabolic biomarkers of human inborn errors of metabolism

21 January 2018

1 reference

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Plasma free amino acid profiling of five types of cancer patients and its application for early detection

21 January 2018

1 reference

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Biliverdin reductase: a major physiologic cytoprotectant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Molecular signatures from omics data: from chaos to consensus

21 January 2018

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Revolutionizing medicine in the 21st century through systems approaches

21 January 2018

1 reference

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Personalizing medicine: a systems biology perspective

21 January 2018

1 reference

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Individuality and epigenetics in obesity.

21 January 2018

1 reference

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Personalized health care: from theory to practice

21 January 2018

1 reference

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Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine

21 January 2018

1 reference

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PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

21 January 2018

1 reference

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Physiologically-based pharmacokinetics in drug development and regulatory science

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Prospects for systems biology and modeling of the gut microbiome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201200275

Symptomatic atherosclerosis is associated with an altered gut metagenome

21 January 2018

1 reference

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A metagenome-wide association study of gut microbiota in type 2 diabetes

21 January 2018

1 reference

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Metagenomic analysis of the human distal gut microbiome

21 January 2018

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A Closer Look at Bacteroides: Phylogenetic Relationship and Genomic Implications of a Life in the Human Gut

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/BIOT.201200275

1 reference

28 August 2017

1 reference

PubMed ID

23613448